lmmol · Proteins

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

UniProt P63092 Organism Homo sapiens Gene GNAS, GNAS1, GSP EC 3.6.5.-

Also known as: GNAS, GNAS1, GSP

Function

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. Functions downstream of beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.

Classification

Family (Pfam)
PF00503 G-alpha
InterPro
Gprotein_alpha_S, Gprotein_alpha_su, GproteinA_insert, P-loop_NTPase
Functional cluster
Small GTPases (Ras/Rab) & related

Experimental structures · PDB · 460

A predicted model is available from AlphaFold.

Gene Ontology · 41

Disease associations

Neighborhood · nearest proteins

GNASGnasGNASGnasGNASGNASGCGR
Nearest neighbours of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 69 cited papers

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