Large ribosomal subunit protein uL13

UniProt P40429 Organism Homo sapiens Gene RPL13A

Also known as: RPL13A

Function

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.

Classification

Family (Pfam): PF00572 Ribosomal_L13
InterPro: Ribosomal_uL13, Ribosomal_uL13_CS, Ribosomal_uL13_euk_arc, Ribosomal_uL13_sf
Functional cluster: Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 155

4UG0 EM
4V6X EM 5.00A
5AJ0 EM 3.50A
5LKS EM 3.60A
5T2C EM 3.60A
6IP5 EM 3.90A
6IP6 EM 4.50A
6IP8 EM 3.90A
6LQM EM 3.09A
6LSR EM 3.13A
6LSS EM 3.23A
6LU8 EM 3.13A
… and 143 more

A predicted model is available from AlphaFold.

Gene Ontology · 24

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein uS17 1 shared papers
Small ribosomal subunit protein uS17 1 shared papers
Bifunctional glutamate/proline--tRNA ligase 2 shared papers
Death-associated protein kinase 3 1 shared papers
Heterogeneous nuclear ribonucleoprotein Q 2 shared papers
Glyceraldehyde-3-phosphate dehydrogenase 2 shared papers
Death-associated protein kinase 1 1 shared papers
Death-associated protein kinase 1 1 shared papers
Bifunctional glutamate/proline--tRNA ligase 1 shared papers
Glyceraldehyde-3-phosphate dehydrogenase 1 shared papers
Large ribosomal subunit protein uL13 1 shared papers
Large ribosomal subunit protein eL29 1 shared papers

Literature · 21 cited papers

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Hum. Mol. Genet. · 2015
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. Mol. Cell. Biol. · 2012
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. Mol. Cell · 2008
… and 9 more in the literature graph

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