Small ribosomal subunit protein uS8

Function

Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Required for proper erythropoiesis.

Classification

Family (Pfam)

PF00410 Ribosomal_S8

InterPro

Ribosomal_uS8, Ribosomal_uS8_CS, Ribosomal_uS8_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 176

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6FEC EM 6.30A
• 6G18 EM 3.60A
• 6G4S EM 4.00A
• … and 164 more

A predicted model is available from AlphaFold.

Gene Ontology · 16

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0070062 extracellular exosome
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0032040 small-subunit processome
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0045787 positive regulation of cell cycle
• GO:0008284 positive regulation of cell population proliferation
• GO:0009615 response to virus
• GO:0042274 ribosomal small subunit biogenesis
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 20 MONDO:0032670

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein uS8 1.00
• Small ribosomal subunit protein uS8 1.00
• Small ribosomal subunit protein uS8 1.00
• Small ribosomal subunit protein uS8 1.00
• Small ribosomal subunit protein uS8 1.00
• Small ribosomal subunit protein uS8 0.98
• Small ribosomal subunit protein uS8z/uS8w 0.93
• Small ribosomal subunit protein uS8 0.93
• Small ribosomal subunit protein uS8 0.93
• Small ribosomal subunit protein uS8x 0.93
• Small ribosomal subunit protein uS8 0.91
• Small ribosomal subunit protein uS8A 0.91

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS8 1 shared papers
• Small ribosomal subunit protein uS8 1 shared papers
• Large ribosomal subunit protein eL38 1 shared papers
• Large ribosomal subunit protein uL6 1 shared papers
• Small ribosomal subunit protein uS7 2 shared papers
• Small ribosomal subunit protein uS17 2 shared papers
• Small ribosomal subunit protein eS12 2 shared papers
• Small ribosomal subunit protein eS19 2 shared papers
• Small ribosomal subunit protein uS13 1 shared papers
• Small ribosomal subunit protein eS24 1 shared papers
• Small ribosomal subunit protein eS21 2 shared papers
• Small ribosomal subunit protein eS27 2 shared papers

Literature · 11 cited papers

• Nucleolar maturation of the human small subunit processome. Science · 2021
• Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia. Haematologica · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Proteomic characterization of the human centrosome by protein correlation profiling. Nature · 2003
• A map of 75 human ribosomal protein genes. Genome Res. · 1998
• Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur. J. Biochem. · 1996
• The primary structure of rat ribosomal protein S15a. Biochem. Biophys. Res. Commun. · 1994