Small ribosomal subunit protein eS19

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam)

PF01090 Ribosomal_S19e

InterPro

Ribosomal_eS19, Ribosomal_eS19_CS, WH-like_DNA-bd_sf, WH_DNA-bd_sf

Functional cluster

Ribosomal S8 & Metabolic Enzymes

Experimental structures · PDB · 173

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6G18 EM 3.60A
• 6G4S EM 4.00A
• 6G4W EM 4.50A
• … and 161 more

A predicted model is available from AlphaFold.

Gene Ontology · 31

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0014069 postsynaptic density
• GO:0005840 ribosome
• GO:0032040 small-subunit processome
• GO:0017134 fibroblast growth factor binding
• GO:0042802 identical protein binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
• GO:0002181 cytoplasmic translation
• GO:0050829 defense response to Gram-negative bacterium
• GO:0030218 erythrocyte differentiation
• GO:0031640 killing of cells of another organism
• GO:0030490 maturation of SSU-rRNA
• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0002548 monocyte chemotaxis
• GO:0060266 negative regulation of respiratory burst involved in inflammatory response
• GO:0007000 nucleolus organization
• GO:0060265 positive regulation of respiratory burst involved in inflammatory response
• GO:0000028 ribosomal small subunit assembly
• GO:0042274 ribosomal small subunit biogenesis
• GO:0006364 rRNA processing
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 1 MONDO:0007110

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein eS19 1.00
• Small ribosomal subunit protein eS19 1.00
• Small ribosomal subunit protein eS19 1.00
• Small ribosomal subunit protein eS19 0.99
• Small ribosomal subunit protein eS19 0.96
• Small ribosomal subunit protein eS19 0.96
• Small ribosomal subunit protein eS19 0.96
• Small ribosomal subunit protein eS19 0.95
• Small ribosomal subunit protein eS19 0.95
• Small ribosomal subunit protein eS19 0.94
• Small ribosomal subunit protein eS19 0.92
• Small ribosomal subunit protein eS19x 0.91

Co-cited proteins · studied together in the literature

• Nucleoprotein 2 shared papers
• Large ribosomal subunit protein eL38 1 shared papers
• Large ribosomal subunit protein uL6 1 shared papers
• Small ribosomal subunit protein uS7 2 shared papers
• Small ribosomal subunit protein uS17 2 shared papers
• Small ribosomal subunit protein uS8 2 shared papers
• Small ribosomal subunit protein eS12 2 shared papers
• Small ribosomal subunit protein uS13 1 shared papers
• Small ribosomal subunit protein eS24 1 shared papers
• Small ribosomal subunit protein eS21 2 shared papers
• Small ribosomal subunit protein eS27 2 shared papers
• Small ribosomal subunit protein uS4 2 shared papers

Literature · 25 cited papers

• Nucleolar maturation of the human small subunit processome. Science · 2021
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Ribosomal protein S19-binding domain provides insights into hantavirus nucleocapsid protein-mediated translation initiation mechanism. Biochem. J. · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol. Cell. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Interaction of hantavirus nucleocapsid protein with ribosomal protein S19. J. Virol. · 2010
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• RPS19 mutations in patients with Diamond-Blackfan anemia. Hum. Mutat. · 2008
• Missense mutations associated with Diamond-Blackfan anemia affect the assembly of ribosomal protein S19 into the ribosome. Hum. Mol. Genet. · 2007
• … and 13 more in the literature graph