Small ribosomal subunit protein eS6

Function

Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam)

PF01092 Ribosomal_S6e

InterPro

Ribosomal_eS6, Ribosomal_eS6-like, Ribosomal_eS6_CS

Functional cluster

Small-Subunit Ribosomal Proteins

Experimental structures · PDB · 181

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6F4P X-ray 1.45A
• 6F4Q X-ray 1.12A
• 6FEC EM 6.30A
• … and 169 more

A predicted model is available from AlphaFold.

Gene Ontology · 33

• GO:0044297 cell body
• GO:0005737 cytoplasm
• GO:0036464 cytoplasmic ribonucleoprotein granule
• GO:0005829 cytosol
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0030425 dendrite
• GO:0005783 endoplasmic reticulum
• GO:0098982 GABA-ergic synapse
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0098793 presynapse
• GO:1990904 ribonucleoprotein complex
• GO:0015935 small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0003729 mRNA binding
• GO:0019901 protein kinase binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0071361 cellular response to ethanol
• GO:0002181 cytoplasmic translation
• GO:0042593 glucose homeostasis
• GO:1903347 negative regulation of bicellular tight junction assembly
• GO:0043065 positive regulation of apoptotic process
• GO:0008284 positive regulation of cell population proliferation
• GO:0032868 response to insulin
• GO:0000028 ribosomal small subunit assembly
• GO:0042274 ribosomal small subunit biogenesis
• GO:0006364 rRNA processing
• GO:0031929 TOR signaling
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein eS6 1.00
• Small ribosomal subunit protein eS6 1.00
• Small ribosomal subunit protein eS6 1.00
• Small ribosomal subunit protein eS6 1.00
• Small ribosomal subunit protein eS6 0.99
• Small ribosomal subunit protein eS6 0.99
• Small ribosomal subunit protein eS6 0.99
• Small ribosomal subunit protein eS6 0.99
• Small ribosomal subunit protein eS6 0.95
• Small ribosomal subunit protein eS6 0.94
• Small ribosomal subunit protein eS6 0.94
• Small ribosomal subunit protein eS6 0.94

Co-cited proteins · studied together in the literature

• E3 SUMO-protein ligase ZBED1 1 shared papers
• PAS domain-containing serine/threonine-protein kinase 1 shared papers
• RCC1 domain-containing protein 1 1 shared papers
• Bifunctional peptidase and arginyl-hydroxylase JMJD5 1 shared papers
• Large ribosomal subunit protein eL24 1 shared papers
• Protein mono-ADP-ribosyltransferase PARP16 1 shared papers
• Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 1 shared papers
• Nuclear receptor subfamily 4immunitygroup A member 1 1 shared papers
• Death-associated protein kinase 1 1 shared papers
• Ribosomal protein S6 kinase alpha-3 1 shared papers
• Tuberin 1 shared papers
• Ribosomal protein S6 kinase alpha-1 1 shared papers

Literature · 27 cited papers

• Nucleolar maturation of the human small subunit processome. Science · 2021
• Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. Cell · 2021
• JMJD5 is a human L-arginyl C-3 hydroxylase. Nat. Commun. · 2018
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN. FEBS J. · 2011
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• … and 15 more in the literature graph