Small ribosomal subunit protein eS8

UniProt P62241 Organism Homo sapiens Gene RPS8

Also known as: RPS8

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam): PF01201 Ribosomal_S8e
InterPro: Ribosomal_eS8, Ribosomal_eS8_CS, Ribosomal_protein_eS8_euk, Ribosomal_Se8/biogenesis_NSA2
Functional cluster: Small-Subunit Ribosomal Proteins

Experimental structures · PDB · 177

4UG0 EM
4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
6G18 EM 3.60A
6G4S EM 4.00A
… and 165 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein eS4, X isoform 2 shared papers
Small ribosomal subunit protein uS13 1 shared papers
Small ribosomal subunit protein eS24 1 shared papers
ELAV-like protein 2 1 shared papers
Small ribosomal subunit protein uS4 2 shared papers
Small ribosomal subunit protein eS1 2 shared papers
Small ribosomal subunit protein uS15 1 shared papers
Small ribosomal subunit protein eS25 1 shared papers
Small ribosomal subunit protein uS19 1 shared papers
Small ribosomal subunit protein uS9 1 shared papers
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein 1 shared papers
Small ribosomal subunit protein uS11 1 shared papers

Literature · 17 cited papers

Nucleolar maturation of the human small subunit processome. Science · 2021
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat. Commun. · 2014
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
… and 5 more in the literature graph

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