Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

Function

May have pro-apoptotic activity.

Classification

Family (Pfam)

PF04758 Ribosomal_S30, PF00240 ubiquitin

InterPro

FUBI, Ribosomal_eS30, Ubiquitin-like_dom, Ubiquitin-like_domsf, Ubiquitin_CS, Ubiquitin_dom

Functional cluster

Serine/Threonine Protein Kinases

Experimental structures · PDB · 170

• 2L7R NMR
• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 6FEC EM 6.30A
• 6G18 EM 3.60A
• 6G4S EM 4.00A
• 6G4W EM 4.50A
• … and 158 more

A predicted model is available from AlphaFold.

Gene Ontology · 21

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0005783 endoplasmic reticulum
• GO:0005615 extracellular space
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0015935 small ribosomal subunit
• GO:0031386 protein tag activity
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019731 antibacterial humoral response
• GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
• GO:0002181 cytoplasmic translation
• GO:0050830 defense response to Gram-positive bacterium
• GO:0002227 innate immune response in mucosa
• GO:0019941 modification-dependent protein catabolic process
• GO:0016567 protein ubiquitination
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein 0.98
• Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein 0.97
• Ubiquitin-like protein FUBI 0.74
• Ubiquitin-like protein FUBI 0.73
• Ubiquitin-like protein FUBI 0.72
• Ubiquitin-like protein FUBI 0.72
• Ubiquitin-like protein FUBI 0.72
• Ubiquitin-like protein FUBI 0.70
• Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein 0.66
• Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein 0.64
• Putative ubiquitin-like protein FUBI-like protein ENSP00000310146 0.64
• Ubiquitin-fold modifier 1 0.64

Co-cited proteins · studied together in the literature

• Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein 1 shared papers
• Small ribosomal subunit protein uS13 1 shared papers
• Small ribosomal subunit protein eS24 1 shared papers
• Small ribosomal subunit protein uS15 1 shared papers
• Small ribosomal subunit protein eS25 1 shared papers
• Small ribosomal subunit protein eS8 1 shared papers
• Small ribosomal subunit protein uS19 1 shared papers
• Small ribosomal subunit protein uS9 1 shared papers
• Small ribosomal subunit protein uS11 1 shared papers
• Small ribosomal subunit protein eS4, X isoform 1 shared papers
• Small ribosomal subunit protein uS7 1 shared papers
• Small ribosomal subunit protein uS17 1 shared papers

Literature · 13 cited papers

• Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36. Elife · 2021
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G. Biochim. Biophys. Acta · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur. J. Biochem. · 1996
• fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus. Oncogene · 1993
• … and 1 more in the literature graph