Tubulin beta-6 chain

UniProt Q9BUF5 Organism Homo sapiens Gene TUBB6

Also known as: TUBB6

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Classification

Family (Pfam): PF00091 Tubulin, PF03953 Tubulin_C
InterPro: Beta-tubulin_BS, Beta_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase
Functional cluster: Tubulins & Mitochondrial Metabolic Enzymes

Gene Ontology · 12

Disease associations

facial palsy, congenital, with ptosis and velopharyngeal dysfunction MONDO:0060589

Drugs targeting this protein · 36

COLCHICINE inhibitor
ANG1005 inhibitor
PLINABULIN inhibitor
CABAZITAXEL inhibitor
IXABEPILONE inhibitor
ERIBULIN MESYLATE inhibitor
ABT-751 inhibitor
DAVUNETIDE stabiliser
CROLIBULIN inhibitor
VINFLUNINE DITARTRATE inhibitor
FOSBRETABULIN TROMETHAMINE disrupting agent
MILATAXEL inhibitor
VINFLUNINE inhibitor
TASIDOTIN inhibitor
SAGOPILONE stabiliser
FOSBRETABULIN DISODIUM inhibitor
DOCETAXEL inhibitor
VINBLASTINE SULFATE inhibitor
DOLASTATIN-10 inhibitor
SOBLIDOTIN inhibitor
LAROTAXEL stabiliser
PACLITAXEL inhibitor
BMS-275183 stabiliser
KOS-1584 stabiliser
T-900607 disrupting agent
PACLITAXEL DOCOSAHEXAENOIC ACID stabiliser
PLOCABULIN inhibitor
VERUBULIN disrupting agent
INDIBULIN inhibitor
VINCRISTINE SULFATE inhibitor
VINORELBINE TARTRATE inhibitor
LEXIBULIN inhibitor
OMBRABULIN inhibitor
DOCETAXEL ANHYDROUS stabiliser
PATUPILONE stabiliser
EPOTHILONE D stabiliser

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Tubulin beta-1 chain 3 shared papers
Tubulin beta-2A chain 3 shared papers
Tubulin beta-4A chain 3 shared papers
Tubulin beta-4B chain 3 shared papers
Tubulin beta-2B chain 3 shared papers
Tubulin beta 8B 2 shared papers
Tubulin beta chain 3 shared papers
Tubulin beta-3 chain 3 shared papers
Tubulin beta-8 chain 2 shared papers
Tubulin polyglutamylase TTLL7 1 shared papers
Tubulin beta-3 chain 1 shared papers
Tubulin alpha-8 chain 1 shared papers

Literature · 11 cited papers

A TUBB6 mutation is associated with autosomal dominant non-progressive congenital facial palsy, bilateral ptosis and velopharyngeal dysfunction. Hum. Mol. Genet. · 2017
Graded control of microtubule severing by tubulin glutamylation. Cell · 2016
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Tumoral and tissue-specific expression of the major human beta-tubulin isotypes. Cytoskeleton · 2010
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell · 2009
Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. Mol. Biol. Cell · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004

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