Tubulin beta-1 chain

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Classification

Family (Pfam)

PF00091 Tubulin, PF03953 Tubulin_C

InterPro

Beta-tubulin_BS, Beta_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase

Functional cluster

Tubulins & Mitochondrial Metabolic Enzymes

Gene Ontology · 21

• GO:0097542 ciliary tip
• GO:0005929 cilium
• GO:0005737 cytoplasm
• GO:0070062 extracellular exosome
• GO:0045171 intercellular bridge
• GO:0005874 microtubule
• GO:0015630 microtubule cytoskeleton
• GO:0072686 mitotic spindle
• GO:0097229 sperm end piece
• GO:0097228 sperm principal piece
• GO:0005525 GTP binding
• GO:0003924 GTPase activity
• GO:0046872 metal ion binding
• GO:0005200 structural constituent of cytoskeleton
• GO:0000226 microtubule cytoskeleton organization
• GO:0046785 microtubule polymerization
• GO:0000278 mitotic cell cycle
• GO:0070527 platelet aggregation
• GO:0030220 platelet formation
• GO:0030878 thyroid gland development
• GO:0070327 thyroid hormone transport

Disease associations

• macrothrombocytopenia, isolated, 1, autosomal dominant MONDO:0800047

Drugs targeting this protein · 36

• COLCHICINE inhibitor
• ANG1005 inhibitor
• PLINABULIN inhibitor
• CABAZITAXEL inhibitor
• IXABEPILONE inhibitor
• ERIBULIN MESYLATE inhibitor
• ABT-751 inhibitor
• DAVUNETIDE stabiliser
• CROLIBULIN inhibitor
• VINFLUNINE DITARTRATE inhibitor
• FOSBRETABULIN TROMETHAMINE disrupting agent
• MILATAXEL inhibitor
• VINFLUNINE inhibitor
• TASIDOTIN inhibitor
• SAGOPILONE stabiliser
• FOSBRETABULIN DISODIUM inhibitor
• DOCETAXEL inhibitor
• VINBLASTINE SULFATE inhibitor
• DOLASTATIN-10 inhibitor
• SOBLIDOTIN inhibitor
• LAROTAXEL stabiliser
• PACLITAXEL inhibitor
• BMS-275183 stabiliser
• KOS-1584 stabiliser
• T-900607 disrupting agent
• PACLITAXEL DOCOSAHEXAENOIC ACID stabiliser
• PLOCABULIN inhibitor
• VERUBULIN disrupting agent
• INDIBULIN inhibitor
• VINCRISTINE SULFATE inhibitor
• VINORELBINE TARTRATE inhibitor
• LEXIBULIN inhibitor
• OMBRABULIN inhibitor
• DOCETAXEL ANHYDROUS stabiliser
• PATUPILONE stabiliser
• EPOTHILONE D stabiliser

Related proteins · sequence + function similarity

• Tubulin beta-1 chain 0.99
• Tubulin beta-2 chain 0.98
• Tubulin beta-6 chain 0.98
• Tubulin beta-2 chain 0.98
• Tubulin beta-9 chain 0.98
• Tubulin beta-3 chain 0.98
• Tubulin beta-3 chain 0.98
• Tubulin beta-5 chain 0.98
• Tubulin beta-3 chain 0.98
• Tubulin beta-6 chain 0.98
• Tubulin beta-5 chain 0.98
• Tubulin beta-3 chain 0.98

Co-cited proteins · studied together in the literature

• Tubulin beta-6 chain 3 shared papers
• Tubulin beta-2A chain 3 shared papers
• Tubulin beta-4A chain 3 shared papers
• Tubulin beta-4B chain 3 shared papers
• Ran-binding protein 10 1 shared papers
• Tubulin beta-2B chain 3 shared papers
• Tubulin beta-1 chain 1 shared papers
• Tubulin beta 8B 2 shared papers
• Ran-binding protein 10 1 shared papers
• Tubulin beta-5 chain 2 shared papers
• Tubulin beta chain 3 shared papers
• Tubulin beta-3 chain 3 shared papers

Literature · 10 cited papers

• Graded control of microtubule severing by tubulin glutamylation. Cell · 2016
• Tumoral and tissue-specific expression of the major human beta-tubulin isotypes. Cytoskeleton · 2010
• Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell · 2009
• Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. Blood · 2009
• RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J. Biol. Chem. · 2008
• Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. Mol. Biol. Cell · 2006
• The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure. Blood · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat. Biotechnol. · 2003
• The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001