Tubulin beta 8B
Also known as: TUBB8B
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Classification
- Family (Pfam)
- PF00091 Tubulin, PF03953 Tubulin_C
- InterPro
- Beta-tubulin_BS, Beta_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase
- Functional cluster
- Tubulins & Mitochondrial Metabolic Enzymes
Gene Ontology · 11
- GO:0005737 cytoplasm
- GO:0070062 extracellular exosome
- GO:0045171 intercellular bridge
- GO:0005874 microtubule
- GO:0072686 mitotic spindle
- GO:0005525 GTP binding
- GO:0003924 GTPase activity
- GO:0046872 metal ion binding
- GO:0005200 structural constituent of cytoskeleton
- GO:0000226 microtubule cytoskeleton organization
- GO:0000278 mitotic cell cycle
Drugs targeting this protein · 1
- ABT-751 inhibitor
Related proteins · sequence + function similarity
- Tubulin beta-8 chain 0.99
- Tubulin beta-8 chain 0.99
- Tubulin beta-8 chain 0.99
- Tubulin beta-3 chain 0.98
- Tubulin beta-3 chain 0.98
- Tubulin beta-3 chain 0.98
- Tubulin beta-3 chain 0.98
- Tubulin beta-3 chain 0.98
- Tubulin beta chain 0.98
- Tubulin beta-5 chain 0.98
- Tubulin beta chain 0.98
- Tubulin beta-7 chain 0.98
Co-cited proteins · studied together in the literature
- Tubulin beta-6 chain 2 shared papers
- Tubulin beta-8 chain 2 shared papers
- Tubulin beta-1 chain 2 shared papers
- Tubulin beta-2A chain 2 shared papers
- Tubulin beta-4A chain 2 shared papers
- Tubulin beta-4B chain 2 shared papers
- Tubulin beta-2B chain 2 shared papers
- Tubulin beta chain 2 shared papers
- Tubulin beta-3 chain 2 shared papers
- Tubulin polyglutamylase TTLL7 1 shared papers
- Tubulin beta-3 chain 1 shared papers
- Tubulin alpha-8 chain 1 shared papers
Literature · 4 cited papers
- Graded control of microtubule severing by tubulin glutamylation. Cell · 2016
- Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell · 2009
- Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. Mol. Biol. Cell · 2006
- DNA sequence and analysis of human chromosome 18. Nature · 2005
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