lmmol · Proteins

Tubulin beta-3 chain

UniProt Q13509 Organism Homo sapiens Gene TUBB3, TUBB4

Also known as: TUBB3, TUBB4

Function

Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord.

Classification

Family (Pfam)
PF00091 Tubulin, PF03953 Tubulin_C
InterPro
Beta-tubulin_BS, Beta_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase
Functional cluster
Tubulins & Mitochondrial Metabolic Enzymes

Experimental structures · PDB · 22

A predicted model is available from AlphaFold.

Gene Ontology · 28

Disease associations

Drugs targeting this protein · 36

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 18 cited papers

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