Tubulin beta-2B chain
Also known as: TUBB2B
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration.
Classification
- Family (Pfam)
- PF00091 Tubulin, PF03953 Tubulin_C
- InterPro
- Beta-tubulin_BS, Beta_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase
- Functional cluster
- Tubulins & Mitochondrial Metabolic Enzymes
Experimental structures · PDB · 2
A predicted model is available from AlphaFold.
Gene Ontology · 23
- GO:0097542 ciliary tip
- GO:0005929 cilium
- GO:0005737 cytoplasm
- GO:0045171 intercellular bridge
- GO:0005874 microtubule
- GO:0015630 microtubule cytoskeleton
- GO:0072686 mitotic spindle
- GO:0005634 nucleus
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0097229 sperm end piece
- GO:0097228 sperm principal piece
- GO:0005525 GTP binding
- GO:0003924 GTPase activity
- GO:0046872 metal ion binding
- GO:0046982 protein heterodimerization activity
- GO:0005200 structural constituent of cytoskeleton
- GO:0021987 cerebral cortex development
- GO:0000226 microtubule cytoskeleton organization
- GO:0007017 microtubule-based process
- GO:0000278 mitotic cell cycle
- GO:0050804 modulation of chemical synaptic transmission
- GO:0001764 neuron migration
- GO:1902669 positive regulation of axon guidance
Disease associations
Drugs targeting this protein · 36
- COLCHICINE inhibitor
- ANG1005 inhibitor
- PLINABULIN inhibitor
- CABAZITAXEL inhibitor
- IXABEPILONE inhibitor
- ERIBULIN MESYLATE inhibitor
- ABT-751 inhibitor
- DAVUNETIDE stabiliser
- CROLIBULIN inhibitor
- VINFLUNINE DITARTRATE inhibitor
- FOSBRETABULIN TROMETHAMINE disrupting agent
- MILATAXEL inhibitor
- VINFLUNINE inhibitor
- TASIDOTIN inhibitor
- SAGOPILONE stabiliser
- FOSBRETABULIN DISODIUM inhibitor
- DOCETAXEL inhibitor
- VINBLASTINE SULFATE inhibitor
- DOLASTATIN-10 inhibitor
- SOBLIDOTIN inhibitor
- LAROTAXEL stabiliser
- PACLITAXEL inhibitor
- BMS-275183 stabiliser
- KOS-1584 stabiliser
- T-900607 disrupting agent
- PACLITAXEL DOCOSAHEXAENOIC ACID stabiliser
- PLOCABULIN inhibitor
- VERUBULIN disrupting agent
- INDIBULIN inhibitor
- VINCRISTINE SULFATE inhibitor
- VINORELBINE TARTRATE inhibitor
- LEXIBULIN inhibitor
- OMBRABULIN inhibitor
- DOCETAXEL ANHYDROUS stabiliser
- PATUPILONE stabiliser
- EPOTHILONE D stabiliser
Related proteins · sequence + function similarity
- Tubulin beta-2B chain 1.00
- Tubulin beta-2B chain 1.00
- Tubulin beta-2B chain 1.00
- Tubulin beta-2 chain 1.00
- Tubulin beta-2A chain 1.00
- Tubulin beta-2A chain 1.00
- Tubulin beta-2A chain 1.00
- Tubulin beta-1 chain 1.00
- Tubulin beta-2A chain 1.00
- Tubulin beta-2 chain 1.00
- Tubulin beta chain 1.00
- Tubulin beta chain 1.00
Co-cited proteins · studied together in the literature
- Tubulin beta chain 2 shared papers
- Kinesin-like protein KIP3 1 shared papers
- Tubulin beta-2B chain 1 shared papers
- Tubulin beta-2B chain 1 shared papers
- Tubulin beta-6 chain 3 shared papers
- Tubulin beta-1 chain 3 shared papers
- Tubulin beta-2A chain 3 shared papers
- Tubulin beta-4A chain 3 shared papers
- Tubulin beta-4B chain 3 shared papers
- Tubulin beta 8B 2 shared papers
- Tubulin beta chain 3 shared papers
- Tubulin beta-3 chain 3 shared papers
Literature · 13 cited papers
- Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability. Hum. Mol. Genet. · 2017
- Graded control of microtubule severing by tubulin glutamylation. Cell · 2016
- De novo TUBB2B mutation causes fetal akinesia deformation sequence with microlissencephaly: An unusual presentation of tubulinopathy. Eur. J. Med. Genet. · 2016
- An inherited TUBB2B mutation alters a kinesin-binding site and causes polymicrogyria, CFEOM and axon dysinnervation. Hum. Mol. Genet. · 2012
- Symmetric polymicrogyria and pachygyria associated with TUBB2B gene mutations. Eur. J. Hum. Genet. · 2012
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- Tumoral and tissue-specific expression of the major human beta-tubulin isotypes. Cytoskeleton · 2010
- Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell · 2009
- Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat. Genet. · 2009
- Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. Mol. Biol. Cell · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- … and 1 more in the literature graph
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