Tubulin beta-8 chain

UniProt Q3ZCM7 Organism Homo sapiens Gene TUBB8

Also known as: TUBB8

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation.

Classification

Family (Pfam): PF00091 Tubulin, PF03953 Tubulin_C
InterPro: Beta-tubulin_BS, Beta_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase
Functional cluster: Tubulins & Mitochondrial Metabolic Enzymes

Gene Ontology · 19

Disease associations

oocyte maturation defect 2 MONDO:0021573

Drugs targeting this protein · 36

COLCHICINE inhibitor
ANG1005 inhibitor
PLINABULIN inhibitor
CABAZITAXEL inhibitor
IXABEPILONE inhibitor
ERIBULIN MESYLATE inhibitor
ABT-751 inhibitor
DAVUNETIDE stabiliser
CROLIBULIN inhibitor
VINFLUNINE DITARTRATE inhibitor
FOSBRETABULIN TROMETHAMINE disrupting agent
MILATAXEL inhibitor
VINFLUNINE inhibitor
TASIDOTIN inhibitor
SAGOPILONE stabiliser
FOSBRETABULIN DISODIUM inhibitor
DOCETAXEL inhibitor
VINBLASTINE SULFATE inhibitor
DOLASTATIN-10 inhibitor
SOBLIDOTIN inhibitor
LAROTAXEL stabiliser
PACLITAXEL inhibitor
BMS-275183 stabiliser
KOS-1584 stabiliser
T-900607 disrupting agent
PACLITAXEL DOCOSAHEXAENOIC ACID stabiliser
PLOCABULIN inhibitor
VERUBULIN disrupting agent
INDIBULIN inhibitor
VINCRISTINE SULFATE inhibitor
VINORELBINE TARTRATE inhibitor
LEXIBULIN inhibitor
OMBRABULIN inhibitor
DOCETAXEL ANHYDROUS stabiliser
PATUPILONE stabiliser
EPOTHILONE D stabiliser

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Tubulin beta-8 chain 1 shared papers
Tubulin beta-8 chain 1 shared papers
Tubulin beta 8B 2 shared papers
Tubulin beta-6 chain 2 shared papers
Tubulin beta-1 chain 2 shared papers
Tubulin beta-2A chain 2 shared papers
Tubulin beta-4A chain 2 shared papers
Tubulin beta-4B chain 2 shared papers
Tubulin beta-2B chain 2 shared papers
Tubulin beta chain 2 shared papers
Tubulin beta-3 chain 2 shared papers
Tubulin polyglutamylase TTLL7 1 shared papers

Literature · 11 cited papers

Two mutations in TUBB8 cause developmental arrest in human oocytes and early embryos. Reprod. BioMed. Online · 2021
Rare homozygous mutation in TUBB8 associated with oocyte maturation defect-2 in a consanguineous mating family. J. Ovarian Res. · 2020
Mutations in TUBB8 cause a multiplicity of phenotypes in human oocytes and early embryos. J. Med. Genet. · 2016
Graded control of microtubule severing by tubulin glutamylation. Cell · 2016
Mutations in TUBB8 and human oocyte meiotic arrest. N. Engl. J. Med. · 2016
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell · 2009
Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. Mol. Biol. Cell · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
The DNA sequence and comparative analysis of human chromosome 10. Nature · 2004
A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes. Am. J. Hum. Genet. · 2002

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