NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Also known as: NDUFB10
Function
Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
Classification
- Family (Pfam)
- PF10249 NDUFB10
- InterPro
- NADH_UbQ_OxRdtase_su10, NDUFB10
- Functional cluster
- Oxidoreductases, Catalases & Peroxidases
Experimental structures · PDB · 7
A predicted model is available from AlphaFold.
Gene Ontology · 7
- GO:0005743 mitochondrial inner membrane
- GO:0005739 mitochondrion
- GO:0045271 respiratory chain complex I
- GO:0008137 NADH dehydrogenase (ubiquinone) activity
- GO:0009060 aerobic respiration
- GO:0006120 mitochondrial electron transport, NADH to ubiquinone
- GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Disease associations
- mitochondrial complex 1 deficiency, nuclear type 35 MONDO:0033560
Drugs targeting this protein · 2
- METFORMIN HYDROCHLORIDE inhibitor
- ME-344 inhibitor
Related proteins · sequence + function similarity
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1.00
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1.00
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1.00
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0.99
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0.97
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0.96
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0.90
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 0.77
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 0.77
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 0.77
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 0.77
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 0.77
Co-cited proteins · studied together in the literature
- Mitochondrial intermembrane space import and assembly protein 40 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 subunit C2 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 2 shared papers
- Acyl carrier protein, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 1 shared papers
Literature · 11 cited papers
- Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly. Hum. Mol. Genet. · 2017
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- The sequence and analysis of duplication-rich human chromosome 16. Nature · 2004
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res. · 2000
- cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. Biochem. Biophys. Res. Commun. · 1998
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.