NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Also known as: NDUFA7
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Classification
- Family (Pfam)
- PF07347 CI-B14_5a
- InterPro
- NDUA7
- Functional cluster
- RRM RNA-Binding & Protein Kinases
Experimental structures · PDB · 7
A predicted model is available from AlphaFold.
Gene Ontology · 7
- GO:0005743 mitochondrial inner membrane
- GO:0005739 mitochondrion
- GO:0045271 respiratory chain complex I
- GO:0008137 NADH dehydrogenase (ubiquinone) activity
- GO:0009060 aerobic respiration
- GO:0006120 mitochondrial electron transport, NADH to ubiquinone
- GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Drugs targeting this protein · 2
- METFORMIN HYDROCHLORIDE inhibitor
- ME-344 inhibitor
Related proteins · sequence + function similarity
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 1.00
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 0.99
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 0.98
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 0.94
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 0.94
- rRNA methyltransferase 1, mitochondrial 0.66
- Small ribosomal subunit protein uS19m 0.60
- Genetic interactor of prohibitin 7, mitochondrial 0.57
- Uncharacterized protein ZK1236.5 0.56
- Small ribosomal subunit protein mS33 0.56
- Mitochondrial-abundant heat soluble protein 0.55
- Minor capsid protein P5 0.54
Co-cited proteins · studied together in the literature
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 subunit C2 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 2 shared papers
- Acyl carrier protein, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 1 shared papers
- Distal membrane-arm assembly complex protein 1 1 shared papers
Literature · 8 cited papers
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res. · 2000
- cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. Biochem. Biophys. Res. Commun. · 1998
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