NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Also known as: NDUFB6
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Classification
- Family (Pfam)
- PF09782 NDUF_B6
- InterPro
- NADH_DH_b-subcmplx_su6
- Functional cluster
- S-Adenosylmethionine Synthases & related
Experimental structures · PDB · 7
A predicted model is available from AlphaFold.
Gene Ontology · 9
- GO:0005743 mitochondrial inner membrane
- GO:0031966 mitochondrial membrane
- GO:0005739 mitochondrion
- GO:0045271 respiratory chain complex I
- GO:0008137 NADH dehydrogenase (ubiquinone) activity
- GO:0009060 aerobic respiration
- GO:0042775 mitochondrial ATP synthesis coupled electron transport
- GO:0006120 mitochondrial electron transport, NADH to ubiquinone
- GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Drugs targeting this protein · 2
- METFORMIN HYDROCHLORIDE inhibitor
- ME-344 inhibitor
Related proteins · sequence + function similarity
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 1.00
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 1.00
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 0.98
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 0.97
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 0.96
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 0.94
- Putative ATP synthase subunit f, mitochondrial 0.69
- Putative ATP synthase subunit f, mitochondrial 0.68
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 0.68
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 0.67
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 0.66
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 0.66
Co-cited proteins · studied together in the literature
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 1 shared papers
- Distal membrane-arm assembly complex protein 1 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 1 shared papers
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial 1 shared papers
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 1 shared papers
- Distal membrane-arm assembly complex protein 2 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 1 shared papers
Literature · 10 cited papers
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- DNA sequence and analysis of human chromosome 9. Nature · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res. · 2000
- Molecular characterization and mutational analysis of the human B17 subunit of the mitochondrial respiratory chain complex I. Hum. Genet. · 1998
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