NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Also known as: NDUFV3
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
Classification
- Family (Pfam)
- PF15880 NDUFV3
- InterPro
- NDUFV3
- Functional cluster
- Eukaryotic Transcription Factors & related
Experimental structures · PDB · 7
A predicted model is available from AlphaFold.
Gene Ontology · 9
- GO:0005743 mitochondrial inner membrane
- GO:0005739 mitochondrion
- GO:0045271 respiratory chain complex I
- GO:0008137 NADH dehydrogenase (ubiquinone) activity
- GO:0003723 RNA binding
- GO:0009060 aerobic respiration
- GO:0042775 mitochondrial ATP synthesis coupled electron transport
- GO:0006120 mitochondrial electron transport, NADH to ubiquinone
- GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Drugs targeting this protein · 2
- METFORMIN HYDROCHLORIDE inhibitor
- ME-344 inhibitor
Related proteins · sequence + function similarity
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 1.00
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 0.99
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 0.96
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 0.87
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 0.87
- Large ribosomal subunit protein mL42 0.71
- Large ribosomal subunit protein mL42 0.70
- Large ribosomal subunit protein mL42 0.69
- Large ribosomal subunit protein mL42 0.68
- Large ribosomal subunit protein mL42 0.67
- Large ribosomal subunit protein mL52 0.65
- Large ribosomal subunit protein mL52 0.65
Co-cited proteins · studied together in the literature
- Trefoil factor 1 1 shared papers
- Trefoil factor 2 1 shared papers
- Trefoil factor 3 1 shared papers
- ATP-binding cassette sub-family G member 1 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 1 shared papers
- Distal membrane-arm assembly complex protein 1 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 1 shared papers
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial 1 shared papers
Literature · 15 cited papers
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
- A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
- Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region. Genomics · 2000
- … and 3 more in the literature graph
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