NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Classification

Family (Pfam)

PF14987 NADHdh_A3

InterPro

NDUFA3

Functional cluster

Photosystem II Reaction-Center & Antimicrobial Peptides

Experimental structures · PDB · 7

• 5XTC EM 3.70A
• 5XTD EM 3.70A
• 5XTH EM 3.90A
• 5XTI EM 17.40A
• 9CWT EM 3.44A
• 9I4I EM 2.63A
• 9TI4 EM 2.66A

A predicted model is available from AlphaFold.

Gene Ontology · 7

• GO:0005743 mitochondrial inner membrane
• GO:0005739 mitochondrion
• GO:0045271 respiratory chain complex I
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0009060 aerobic respiration
• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Drugs targeting this protein · 2

• METFORMIN HYDROCHLORIDE inhibitor
• ME-344 inhibitor

Related proteins · sequence + function similarity

• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 1.00
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 0.99
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 0.95
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 0.94
• ATP synthase subunit J, mitochondrial 0.75
• Uncharacterized protein C3H7.08c 0.74
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 0.73
• Uncharacterized protein PB8E5.10 0.71
• ATP synthase subunit J, mitochondrial 0.71
• Cytochrome c oxidase assembly factor 3, mitochondrial 0.70
• Cytochrome b-c1 complex subunit 10 0.69
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 0.69

Co-cited proteins · studied together in the literature

• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 2 shared papers
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 2 shared papers
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 2 shared papers
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial 2 shared papers
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 2 shared papers
• NADH dehydrogenase [ubiquinone] 1 subunit C2 2 shared papers
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 2 shared papers
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 2 shared papers
• Acyl carrier protein, mitochondrial 2 shared papers
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 1 shared papers
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 1 shared papers
• Distal membrane-arm assembly complex protein 1 1 shared papers

Literature · 9 cited papers

• Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
• Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res. · 2000
• cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. Biochem. Biophys. Res. Commun. · 1998