NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Also known as: NDUFB4
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Classification
- Family (Pfam)
- PF07225 NDUF_B4
- InterPro
- NADH_UbQ_OxRdtase_NDUFB4_su
- Functional cluster
- Bacterial Ribosomal Proteins
Experimental structures · PDB · 7
A predicted model is available from AlphaFold.
Gene Ontology · 7
- GO:0005743 mitochondrial inner membrane
- GO:0005739 mitochondrion
- GO:0045271 respiratory chain complex I
- GO:0008137 NADH dehydrogenase (ubiquinone) activity
- GO:0009060 aerobic respiration
- GO:0006120 mitochondrial electron transport, NADH to ubiquinone
- GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Drugs targeting this protein · 2
- METFORMIN HYDROCHLORIDE inhibitor
- ME-344 inhibitor
Related proteins · sequence + function similarity
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 1.00
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 1.00
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 1.00
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 1.00
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 0.96
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 0.96
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 0.88
- Cytochrome c oxidase assembly factor 3, mitochondrial 0.77
- Cytochrome c oxidase assembly factor 3, mitochondrial 0.77
- Cytochrome c oxidase assembly factor 3, mitochondrial 0.76
- Putative ATP synthase subunit f, mitochondrial 0.76
- Cytochrome c oxidase assembly factor 3, mitochondrial 0.75
Co-cited proteins · studied together in the literature
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 subunit C2 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 2 shared papers
- Acyl carrier protein, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 1 shared papers
- Distal membrane-arm assembly complex protein 1 1 shared papers
Literature · 9 cited papers
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
- N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
- cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. Biochem. Biophys. Res. Commun. · 1998
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