NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Also known as: NDUFA10
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Classification
- Family (Pfam)
- PF01712 dNK
- InterPro
- Deoxyribonucleoside_kinase, DNK_dom, NDUFA10, P-loop_NTPase
- Functional cluster
- S-Adenosylmethionine Synthases & related
Experimental structures · PDB · 6
A predicted model is available from AlphaFold.
Gene Ontology · 9
- GO:0005737 cytoplasm
- GO:0005743 mitochondrial inner membrane
- GO:0005759 mitochondrial matrix
- GO:0005739 mitochondrion
- GO:0045271 respiratory chain complex I
- GO:0008137 NADH dehydrogenase (ubiquinone) activity
- GO:0009060 aerobic respiration
- GO:0006120 mitochondrial electron transport, NADH to ubiquinone
- GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Disease associations
- mitochondrial complex I deficiency, nuclear type 22 MONDO:0032626
Drugs targeting this protein · 2
- METFORMIN HYDROCHLORIDE inhibitor
- ME-344 inhibitor
Related proteins · sequence + function similarity
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 1.00
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 1.00
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 1.00
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0.99
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0.97
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0.97
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0.94
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0.84
- Deoxycytidine kinase 0.56
- Deoxycytidine kinase 1 0.52
- Deoxynucleoside kinase 0.52
- Phosphoribulokinase 0.51
Co-cited proteins · studied together in the literature
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 subunit C2 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 2 shared papers
- Protoheme IX farnesyltransferase, mitochondrial 1 shared papers
- Acyl carrier protein, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial 2 shared papers
- NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 1 shared papers
Literature · 10 cited papers
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
- A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain complex deficiencies. PLoS Genet. · 2016
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- NDUFA10 mutations cause complex I deficiency in a patient with Leigh disease. Eur. J. Hum. Genet. · 2011
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
- cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. Biochem. Biophys. Res. Commun. · 1998
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