NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Also known as: NDUFA5
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Classification
- Family (Pfam)
- PF04716 ETC_C1_NDUFA5
- InterPro
- NDUFA5
- Functional cluster
- Mixed Regulatory & Membrane Proteins
Experimental structures · PDB · 7
A predicted model is available from AlphaFold.
Gene Ontology · 8
- GO:0005743 mitochondrial inner membrane
- GO:0005739 mitochondrion
- GO:0045271 respiratory chain complex I
- GO:0008137 NADH dehydrogenase (ubiquinone) activity
- GO:0009060 aerobic respiration
- GO:0006120 mitochondrial electron transport, NADH to ubiquinone
- GO:0042776 proton motive force-driven mitochondrial ATP synthesis
- GO:0022904 respiratory electron transport chain
Drugs targeting this protein · 2
- METFORMIN HYDROCHLORIDE inhibitor
- ME-344 inhibitor
Related proteins · sequence + function similarity
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 1.00
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 1.00
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 1.00
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0.98
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0.98
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0.98
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0.97
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0.96
- Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5, mitochondrial 0.85
- Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0.72
- Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0.71
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit MCI4 0.67
Co-cited proteins · studied together in the literature
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 1 shared papers
- Distal membrane-arm assembly complex protein 1 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 1 shared papers
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial 1 shared papers
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 1 shared papers
- Distal membrane-arm assembly complex protein 2 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 1 shared papers
Literature · 13 cited papers
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
- The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- The DNA sequence of human chromosome 7. Nature · 2003
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
- Genomic organization of the human complex I 13-kDa subunit gene NDUFA5. Cytogenet. Cell Genet. · 1999
- A human cDNA encoding the homologue of NADH:ubiquinone oxidoreductase subunit B13. Biochim. Biophys. Acta · 1997
- … and 1 more in the literature graph
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