Voltage-dependent calcium channel gamma-4 subunit

Function

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

Classification

Family (Pfam)

PF00822 PMP22_Claudin

InterPro

CACNG_subunit, PMP22/EMP/MP20/Claudin, VDCC_g4su, VDCC_gsu

Functional cluster

Mixed Regulatory & Membrane Proteins

Gene Ontology · 19

• GO:0032281 AMPA glutamate receptor complex
• GO:0044297 cell body
• GO:0009986 cell surface
• GO:0030666 endocytic vesicle membrane
• GO:0098978 glutamatergic synapse
• GO:1990454 L-type voltage-gated calcium channel complex
• GO:0005886 plasma membrane
• GO:0098839 postsynaptic density membrane
• GO:0036477 somatodendritic compartment
• GO:0005246 calcium channel regulator activity
• GO:0016247 channel regulator activity
• GO:0035255 ionotropic glutamate receptor binding
• GO:0005245 voltage-gated calcium channel activity
• GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
• GO:0051968 positive regulation of synaptic transmission, glutamatergic
• GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
• GO:2000311 regulation of AMPA receptor activity
• GO:0042220 response to cocaine
• GO:0019226 transmission of nerve impulse

Drugs targeting this protein · 9

• PREGABALIN modulator
• BEPRIDIL HYDROCHLORIDE blocker
• GABAPENTIN ENACARBIL modulator
• IMAGABALIN modulator
• SULOCTIDIL blocker
• PHLOROGLUCINOL blocker
• TERODILINE HYDROCHLORIDE blocker
• ATAGABALIN modulator
• GABAPENTIN modulator

Related proteins · sequence + function similarity

• Voltage-dependent calcium channel gamma-4 subunit 1.00
• Voltage-dependent calcium channel gamma-4 subunit 1.00
• Voltage-dependent calcium channel gamma-2 subunit 0.90
• Voltage-dependent calcium channel gamma-2 subunit 0.90
• Voltage-dependent calcium channel gamma-2 subunit 0.90
• Voltage-dependent calcium channel gamma-3 subunit 0.90
• Voltage-dependent calcium channel gamma-3 subunit 0.90
• Voltage-dependent calcium channel gamma-3 subunit 0.90
• Voltage-dependent calcium channel gamma-3 subunit 0.89
• Voltage-dependent calcium channel gamma-3 subunit 0.89
• Voltage-dependent calcium channel gamma-3 subunit 0.89
• Voltage-dependent calcium channel gamma-5 subunit 0.84

Co-cited proteins · studied together in the literature

• Voltage-dependent calcium channel gamma-5 subunit 1 shared papers
• Glutamate receptor 4 1 shared papers
• Voltage-dependent calcium channel gamma-8 subunit 2 shared papers
• Voltage-dependent calcium channel gamma-7 subunit 2 shared papers
• Voltage-dependent calcium channel gamma-8 subunit 2 shared papers
• Voltage-dependent L-type calcium channel subunit beta-1 1 shared papers
• Voltage-dependent calcium channel gamma-6 subunit 1 shared papers
• Voltage-dependent calcium channel gamma-6 subunit 1 shared papers
• Glutamate receptor 1 1 shared papers
• Glutamate receptor 3 1 shared papers
• Protein cornichon homolog 2 1 shared papers
• Voltage-dependent L-type calcium channel subunit beta-1 1 shared papers

Literature · 5 cited papers

• Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron · 2010
• Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits. FASEB J. · 2011
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Genome Res. · 1999