Glutamate receptor 3

UniProt P42263 Organism Homo sapiens Gene GLUR3, GLURC, GRIA3, GluA3

Also known as: GLUR3, GLURC, GRIA3, GluA3

Function

Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Classification

Family (Pfam): PF01094 ANF_receptor, PF00060 Lig_chan, PF10613 Lig_chan-Glu_bd
InterPro: ANF_lig-bd_rcpt, Glu/Gly-bd, Iono_Glu_rcpt_met, Ionotropic_Glu_rcpt, Iontro_rcpt_C, Peripla_BP_I
Functional cluster: Immunoglobulin-Domain Cell Adhesion Proteins

Gene Ontology · 19

Disease associations

syndromic X-linked intellectual disability 94 MONDO:0010402

Drugs targeting this protein · 12

ZONAMPANEL antagonist
PERAMPANEL antagonist
FARAMPATOR positive allosteric modulator
MIBAMPATOR positive allosteric modulator
DASOLAMPANEL antagonist
TOPIRAMATE antagonist
IRAMPANEL antagonist
SELURAMPANEL antagonist
BECAMPANEL antagonist
TEZAMPANEL antagonist
OSAVAMPATOR positive allosteric modulator
PESAMPATOR positive allosteric modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Zinc finger MYM-type protein 3 1 shared papers
Gamma-aminobutyric acid receptor subunit alpha-3 1 shared papers
Sodium channel protein type 2 subunit alpha 1 shared papers
Glutamate receptor 4 1 shared papers
Voltage-dependent calcium channel gamma-4 subunit 1 shared papers
Voltage-dependent calcium channel gamma-8 subunit 1 shared papers
Glutamate receptor 1 1 shared papers
Protein cornichon homolog 2 1 shared papers
Voltage-dependent calcium channel gamma-7 subunit 1 shared papers
Voltage-dependent calcium channel gamma-8 subunit 1 shared papers
Glutamate receptor 1 1 shared papers
Glutamate receptor 2 1 shared papers

Literature · 8 cited papers

Dominant SCN2A Mutation Causes Familial Episodic Ataxia and Impairment of Speech Development. Neuropediatrics · 2018
X-exome sequencing in Finnish families with intellectual disability--four novel mutations and two novel syndromic phenotypes. Orphanet J. Rare Dis. · 2014
Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron · 2010
Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans. Proc. Natl. Acad. Sci. U.S.A. · 2007
The DNA sequence of the human X chromosome. Nature · 2005
Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation. Genomics · 1999
Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. Am. J. Med. Genet. · 2000
Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins. Biochim. Biophys. Acta · 1994

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.