Voltage-dependent calcium channel gamma-7 subunit
Also known as: CACNG7
Function
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2.
Classification
- Family (Pfam)
- PF13903 Claudin_2
- InterPro
- CACNG_subunit, PMP22/EMP/MP20/Claudin, VDCC_g7su, VDCC_gsu
- Functional cluster
- Mixed Regulatory & Membrane Proteins
Gene Ontology · 20
- GO:0032281 AMPA glutamate receptor complex
- GO:0044300 cerebellar mossy fiber
- GO:0005769 early endosome
- GO:0098978 glutamatergic synapse
- GO:1990454 L-type voltage-gated calcium channel complex
- GO:0043025 neuronal cell body
- GO:0005886 plasma membrane
- GO:0098839 postsynaptic density membrane
- GO:0005891 voltage-gated calcium channel complex
- GO:0005246 calcium channel regulator activity
- GO:0016247 channel regulator activity
- GO:0005245 voltage-gated calcium channel activity
- GO:0006816 calcium ion transport
- GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
- GO:1903861 positive regulation of dendrite extension
- GO:0051968 positive regulation of synaptic transmission, glutamatergic
- GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
- GO:2000311 regulation of AMPA receptor activity
- GO:0043488 regulation of mRNA stability
- GO:0019226 transmission of nerve impulse
Drugs targeting this protein · 9
- PREGABALIN modulator
- BEPRIDIL HYDROCHLORIDE blocker
- GABAPENTIN ENACARBIL modulator
- IMAGABALIN modulator
- SULOCTIDIL blocker
- PHLOROGLUCINOL blocker
- TERODILINE HYDROCHLORIDE blocker
- ATAGABALIN modulator
- GABAPENTIN modulator
Related proteins · sequence + function similarity
- Voltage-dependent calcium channel gamma-7 subunit 1.00
- Voltage-dependent calcium channel gamma-5 subunit 0.97
- Voltage-dependent calcium channel gamma-5 subunit 0.97
- Voltage-dependent calcium channel gamma-5 subunit 0.96
- Transmembrane protein 178B 0.81
- Voltage-dependent calcium channel gamma-4 subunit 0.81
- Voltage-dependent calcium channel gamma-4 subunit 0.81
- Voltage-dependent calcium channel gamma-4 subunit 0.81
- Transmembrane protein 178B 0.80
- LHFPL tetraspan subfamily member 4 protein 0.80
- LHFPL tetraspan subfamily member 4 protein 0.79
- LHFPL tetraspan subfamily member 4 protein 0.79
Co-cited proteins · studied together in the literature
- Voltage-dependent calcium channel gamma-7 subunit 2 shared papers
- Voltage-dependent calcium channel gamma-6 subunit 3 shared papers
- Voltage-dependent calcium channel gamma-8 subunit 4 shared papers
- Voltage-dependent calcium channel gamma-5 subunit 2 shared papers
- Voltage-dependent calcium channel gamma-8 subunit 3 shared papers
- Voltage-dependent calcium channel gamma-4 subunit 2 shared papers
- Glutamate receptor 4 1 shared papers
- Voltage-dependent calcium channel gamma-6 subunit 2 shared papers
- Voltage-dependent calcium channel gamma-6 subunit 2 shared papers
- Voltage-dependent calcium channel gamma-4 subunit 2 shared papers
- Voltage-dependent calcium channel gamma-7 subunit 2 shared papers
- Voltage-dependent L-type calcium channel subunit beta-1 1 shared papers
Literature · 6 cited papers
- Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron · 2010
- Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits. FASEB J. · 2011
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. EMBO J. · 2002
- Calcium channel gamma subunits provide insights into the evolution of this gene family. Gene · 2001
- A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. Genomics · 2001
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