Voltage-dependent calcium channel gamma-5 subunit
Also known as: CACNG5
Function
Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
Classification
- Family (Pfam)
- PF13903 Claudin_2
- InterPro
- CACNG_subunit, PMP22/EMP/MP20/Claudin, VDCC_g5su, VDCC_gsu
- Functional cluster
- Respiratory Chain & ATP Synthase Subunits
Gene Ontology · 11
- GO:0032281 AMPA glutamate receptor complex
- GO:0098978 glutamatergic synapse
- GO:0014069 postsynaptic density
- GO:0098839 postsynaptic density membrane
- GO:0016247 channel regulator activity
- GO:0015075 monoatomic ion transmembrane transporter activity
- GO:0005245 voltage-gated calcium channel activity
- GO:0051968 positive regulation of synaptic transmission, glutamatergic
- GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
- GO:2000311 regulation of AMPA receptor activity
- GO:0019226 transmission of nerve impulse
Drugs targeting this protein · 9
- PREGABALIN modulator
- BEPRIDIL HYDROCHLORIDE blocker
- GABAPENTIN ENACARBIL modulator
- IMAGABALIN modulator
- SULOCTIDIL blocker
- PHLOROGLUCINOL blocker
- TERODILINE HYDROCHLORIDE blocker
- ATAGABALIN modulator
- GABAPENTIN modulator
Related proteins · sequence + function similarity
- Voltage-dependent calcium channel gamma-5 subunit 1.00
- Voltage-dependent calcium channel gamma-5 subunit 1.00
- Voltage-dependent calcium channel gamma-7 subunit 0.96
- Voltage-dependent calcium channel gamma-7 subunit 0.96
- Voltage-dependent calcium channel gamma-7 subunit 0.96
- Voltage-dependent calcium channel gamma-4 subunit 0.84
- Voltage-dependent calcium channel gamma-4 subunit 0.84
- Voltage-dependent calcium channel gamma-4 subunit 0.84
- Transmembrane protein 178B 0.77
- Transmembrane protein 178B 0.77
- Voltage-dependent calcium channel gamma-2 subunit 0.76
- Voltage-dependent calcium channel gamma-2 subunit 0.76
Co-cited proteins · studied together in the literature
- Voltage-dependent calcium channel gamma-4 subunit 1 shared papers
- Voltage-dependent calcium channel gamma-7 subunit 2 shared papers
- Voltage-dependent calcium channel gamma-7 subunit 2 shared papers
- Voltage-dependent calcium channel gamma-like subunit 1 shared papers
- Voltage-dependent calcium channel gamma-like subunit 1 shared papers
- Voltage-dependent calcium channel gamma-5 subunit 1 shared papers
- Voltage-dependent calcium channel gamma-6 subunit 1 shared papers
- Voltage-dependent calcium channel gamma-6 subunit 1 shared papers
- Voltage-dependent calcium channel gamma-6 subunit 1 shared papers
- Voltage-dependent calcium channel gamma-3 subunit 1 shared papers
- Voltage-dependent calcium channel gamma-5 subunit 1 shared papers
- Voltage-dependent calcium channel gamma-8 subunit 1 shared papers
Literature · 5 cited papers
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. EMBO J. · 2002
- Calcium channel gamma subunits provide insights into the evolution of this gene family. Gene · 2001
- Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Genome Res. · 1999
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