Voltage-dependent calcium channel gamma-2 subunit
Also known as: CACNG2
Function
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Classification
- Family (Pfam)
- PF00822 PMP22_Claudin
- InterPro
- CACNG_subunit, PMP22/EMP/MP20/Claudin, VDCC_g2su, VDCC_gsu
- Functional cluster
- Membrane Transporters & GPCRs
Experimental structures · PDB · 5
A predicted model is available from AlphaFold.
Gene Ontology · 23
- GO:0032281 AMPA glutamate receptor complex
- GO:0009986 cell surface
- GO:0044300 cerebellar mossy fiber
- GO:0030666 endocytic vesicle membrane
- GO:0098978 glutamatergic synapse
- GO:0098686 hippocampal mossy fiber to CA3 synapse
- GO:0005886 plasma membrane
- GO:0098839 postsynaptic density membrane
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0036477 somatodendritic compartment
- GO:0005891 voltage-gated calcium channel complex
- GO:0016247 channel regulator activity
- GO:0035255 ionotropic glutamate receptor binding
- GO:0005245 voltage-gated calcium channel activity
- GO:0060082 eye blink reflex
- GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
- GO:1904510 positive regulation of protein localization to basolateral plasma membrane
- GO:0051968 positive regulation of synaptic transmission, glutamatergic
- GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
- GO:0006612 protein targeting to membrane
- GO:2000311 regulation of AMPA receptor activity
- GO:0051592 response to calcium ion
- GO:0019226 transmission of nerve impulse
Disease associations
- intellectual disability, autosomal dominant 10 MONDO:0013657
Drugs targeting this protein · 9
- PREGABALIN modulator
- BEPRIDIL HYDROCHLORIDE blocker
- GABAPENTIN ENACARBIL modulator
- IMAGABALIN modulator
- SULOCTIDIL blocker
- PHLOROGLUCINOL blocker
- TERODILINE HYDROCHLORIDE blocker
- ATAGABALIN modulator
- GABAPENTIN modulator
Related proteins · sequence + function similarity
- Voltage-dependent calcium channel gamma-2 subunit 1.00
- Voltage-dependent calcium channel gamma-2 subunit 1.00
- Voltage-dependent calcium channel gamma-3 subunit 0.97
- Voltage-dependent calcium channel gamma-3 subunit 0.97
- Voltage-dependent calcium channel gamma-3 subunit 0.97
- Voltage-dependent calcium channel gamma-3 subunit 0.97
- Voltage-dependent calcium channel gamma-3 subunit 0.96
- Voltage-dependent calcium channel gamma-3 subunit 0.96
- Voltage-dependent calcium channel gamma-4 subunit 0.90
- Voltage-dependent calcium channel gamma-4 subunit 0.90
- Voltage-dependent calcium channel gamma-4 subunit 0.89
- Voltage-dependent calcium channel gamma-5 subunit 0.76
Co-cited proteins · studied together in the literature
- Voltage-dependent calcium channel gamma-3 subunit 1 shared papers
- Band 4.1-like protein 1 1 shared papers
- Kinesin-like protein KIF1A 1 shared papers
- Protein cornichon homolog 2 1 shared papers
- Protein cornichon homolog 2 1 shared papers
- Protein cornichon homolog 3 1 shared papers
- Glutamate receptor ionotropic, NMDA 1 1 shared papers
- Glutamate receptor 1 1 shared papers
- Protein cornichon homolog 2 1 shared papers
- Voltage-dependent calcium channel gamma-8 subunit 1 shared papers
- Voltage-dependent calcium channel gamma-2 subunit 1 shared papers
- Glutamate receptor 1 1 shared papers
Literature · 7 cited papers
- Mechanisms of channel block in calcium-permeable AMPA receptors. Neuron · 2018
- Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Am. J. Hum. Genet. · 2011
- Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proc. Natl. Acad. Sci. U.S.A. · 2010
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. · 2004
- The DNA sequence of human chromosome 22. Nature · 1999
- Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications. Mayo Clin. Proc. · 1999
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