lmmol · Proteins

Glutamate receptor ionotropic, NMDA 1

UniProt Q05586 Organism Homo sapiens Gene GRIN1, NMDAR1

Also known as: GRIN1, NMDAR1

Function

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

Classification

Family (Pfam)
PF01094 ANF_receptor, PF00060 Lig_chan, PF10613 Lig_chan-Glu_bd
InterPro
ANF_lig-bd_rcpt, Glu/Gly-bd, Iono_Glu_rcpt_met, Ionotropic_Glu_rcpt, Iontro_rcpt_C, NMDA1-like_ligand-bd, NMDA1-like_N, Peripla_BP_I
Functional cluster
Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 71

A predicted model is available from AlphaFold.

Gene Ontology · 56

Disease associations

Drugs targeting this protein · 24

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 33 cited papers

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