lmmol · Proteins

Glutamate receptor ionotropic, NMDA 3A

UniProt Q8TCU5 Organism Homo sapiens Gene GRIN3A, KIAA1973

Also known as: GRIN3A, KIAA1973

Function

Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+) (By similarity). During the development of neural circuits, participates in the synaptic refinement period, restricting spine maturation and growth (By similarity). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity). Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. GluN3A subunit also binds D-serine (By similarity). Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity). By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses (By similarity).

Classification

Family (Pfam)
PF01094 ANF_receptor, PF00060 Lig_chan, PF10613 Lig_chan-Glu_bd
InterPro
ANF_lig-bd_rcpt, Glu/Gly-bd, Iono_Glu_rcpt_met, Ionotropic_Glu_rcpt, Iontro_rcpt_C, Peripla_BP_I
Functional cluster
RNA Polymerase & tRNA Deacylases

Experimental structures · PDB · 3

A predicted model is available from AlphaFold.

Gene Ontology · 32

Drugs targeting this protein · 20

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 9 cited papers

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