lmmol · Proteins

Glutamate receptor ionotropic, NMDA 2A

UniProt Q12879 Organism Homo sapiens Gene GRIN2A, NMDAR2A

Also known as: GRIN2A, NMDAR2A

Function

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity).

Classification

Family (Pfam)
PF01094 ANF_receptor, PF00060 Lig_chan, PF10613 Lig_chan-Glu_bd, PF10565 NMDAR2_C
InterPro
ANF_lig-bd_rcpt, Glu/Gly-bd, Iono_Glu_rcpt_met, Ionotropic_Glu_rcpt, Iontro_rcpt_C, NMDAR2_C, Peripla_BP_I
Functional cluster
Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 36

A predicted model is available from AlphaFold.

Gene Ontology · 37

Disease associations

Drugs targeting this protein · 21

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 32 cited papers

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