lmmol · Proteins

Glutamate receptor ionotropic, NMDA 3B

UniProt O60391 Organism Homo sapiens Gene GRIN3B

Also known as: GRIN3B

Function

Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+) (By similarity). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity). Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. GluN3B subunit also binds D-serine and, in the absence of glycine, activates glycinergic receptor complexes, but with lower efficacy than glycine (By similarity). Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity).

Classification

Family (Pfam)
PF00060 Lig_chan, PF10613 Lig_chan-Glu_bd
InterPro
Glu/Gly-bd, Iono_Glu_rcpt_met, Ionotropic_Glu_rcpt, Iontro_rcpt_C, Peripla_BP_I
Functional cluster
Nucleic Acid Metabolism & Repair Enzymes

Gene Ontology · 21

Drugs targeting this protein · 20

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 5 cited papers

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.