Voltage-dependent calcium channel gamma-8 subunit

Function

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.

Classification

Family (Pfam)

PF00822 PMP22_Claudin

InterPro

CACNG_subunit, PMP22/EMP/MP20/Claudin, VDCC_g8su, VDCC_gsu

Functional cluster

Mixed Regulatory & Membrane Proteins

Gene Ontology · 19

• GO:0032281 AMPA glutamate receptor complex
• GO:0032590 dendrite membrane
• GO:0030666 endocytic vesicle membrane
• GO:0098978 glutamatergic synapse
• GO:1990454 L-type voltage-gated calcium channel complex
• GO:0005886 plasma membrane
• GO:0014069 postsynaptic density
• GO:0098839 postsynaptic density membrane
• GO:0005891 voltage-gated calcium channel complex
• GO:0005246 calcium channel regulator activity
• GO:0016247 channel regulator activity
• GO:0035255 ionotropic glutamate receptor binding
• GO:0030346 protein phosphatase 2B binding
• GO:0005245 voltage-gated calcium channel activity
• GO:0006816 calcium ion transport
• GO:0051968 positive regulation of synaptic transmission, glutamatergic
• GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
• GO:2000311 regulation of AMPA receptor activity
• GO:0019226 transmission of nerve impulse

Drugs targeting this protein · 9

• PREGABALIN modulator
• BEPRIDIL HYDROCHLORIDE blocker
• GABAPENTIN ENACARBIL modulator
• IMAGABALIN modulator
• SULOCTIDIL blocker
• PHLOROGLUCINOL blocker
• TERODILINE HYDROCHLORIDE blocker
• ATAGABALIN modulator
• GABAPENTIN modulator

Related proteins · sequence + function similarity

• Voltage-dependent calcium channel gamma-8 subunit 0.99
• Voltage-dependent calcium channel gamma-8 subunit 0.99
• Voltage-dependent calcium channel gamma-4 subunit 0.74
• Voltage-dependent calcium channel gamma-4 subunit 0.74
• Phospholipid phosphatase-related protein type 3 0.73
• Voltage-dependent calcium channel gamma-4 subunit 0.73
• Voltage-dependent calcium channel gamma-7 subunit 0.69
• Voltage-dependent calcium channel gamma-7 subunit 0.69
• Voltage-dependent calcium channel gamma-7 subunit 0.69
• One cut domain family member 3 0.68
• Zinc finger protein AEBP2 0.67
• Phospholipid phosphatase-related protein type 3 0.67

Co-cited proteins · studied together in the literature

• Voltage-dependent calcium channel gamma-6 subunit 3 shared papers
• Voltage-dependent calcium channel gamma-7 subunit 4 shared papers
• Voltage-dependent calcium channel gamma-8 subunit 3 shared papers
• Glutamate receptor 1 2 shared papers
• Protein cornichon homolog 2 2 shared papers
• Voltage-dependent calcium channel gamma-4 subunit 2 shared papers
• Glutamate receptor 4 1 shared papers
• Voltage-dependent calcium channel gamma-6 subunit 2 shared papers
• Voltage-dependent calcium channel gamma-6 subunit 2 shared papers
• Protein cornichon homolog 2 1 shared papers
• Protein cornichon homolog 2 1 shared papers
• Protein cornichon homolog 3 1 shared papers

Literature · 6 cited papers

• Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron · 2010
• Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits. FASEB J. · 2011
• Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proc. Natl. Acad. Sci. U.S.A. · 2010
• The DNA sequence and biology of human chromosome 19. Nature · 2004
• Calcium channel gamma subunits provide insights into the evolution of this gene family. Gene · 2001
• A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. Genomics · 2001