Voltage-dependent calcium channel gamma-3 subunit
Also known as: CACNG3
Function
Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Classification
- Family (Pfam)
- PF00822 PMP22_Claudin
- InterPro
- CACNG_subunit, PMP22/EMP/MP20/Claudin, VDCC_gsu
- Functional cluster
- Membrane Transporters & GPCRs
Gene Ontology · 22
- GO:0032281 AMPA glutamate receptor complex
- GO:0030425 dendrite
- GO:0030666 endocytic vesicle membrane
- GO:0060076 excitatory synapse
- GO:0098978 glutamatergic synapse
- GO:0005886 plasma membrane
- GO:0098839 postsynaptic density membrane
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0036477 somatodendritic compartment
- GO:0005891 voltage-gated calcium channel complex
- GO:0016247 channel regulator activity
- GO:0035255 ionotropic glutamate receptor binding
- GO:0030165 PDZ domain binding
- GO:0005245 voltage-gated calcium channel activity
- GO:0006816 calcium ion transport
- GO:0008104 intracellular protein localization
- GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
- GO:0051968 positive regulation of synaptic transmission, glutamatergic
- GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
- GO:0006605 protein targeting
- GO:2000311 regulation of AMPA receptor activity
- GO:0019226 transmission of nerve impulse
Drugs targeting this protein · 9
- PREGABALIN modulator
- BEPRIDIL HYDROCHLORIDE blocker
- GABAPENTIN ENACARBIL modulator
- IMAGABALIN modulator
- SULOCTIDIL blocker
- PHLOROGLUCINOL blocker
- TERODILINE HYDROCHLORIDE blocker
- ATAGABALIN modulator
- GABAPENTIN modulator
Related proteins · sequence + function similarity
- Voltage-dependent calcium channel gamma-3 subunit 1.00
- Voltage-dependent calcium channel gamma-3 subunit 1.00
- Voltage-dependent calcium channel gamma-3 subunit 1.00
- Voltage-dependent calcium channel gamma-3 subunit 1.00
- Voltage-dependent calcium channel gamma-3 subunit 1.00
- Voltage-dependent calcium channel gamma-2 subunit 0.97
- Voltage-dependent calcium channel gamma-2 subunit 0.97
- Voltage-dependent calcium channel gamma-2 subunit 0.97
- Voltage-dependent calcium channel gamma-4 subunit 0.89
- Voltage-dependent calcium channel gamma-4 subunit 0.89
- Voltage-dependent calcium channel gamma-4 subunit 0.89
- Voltage-dependent calcium channel gamma-5 subunit 0.74
Co-cited proteins · studied together in the literature
- Voltage-dependent calcium channel gamma-2 subunit 1 shared papers
Literature · 3 cited papers
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics · 1999
- Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications. Mayo Clin. Proc. · 1999
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