Large ribosomal subunit protein uL22

UniProt P61175 Organism Escherichia coli (strain K12) Gene JW3277, b3315, eryB, rplV

Also known as: JW3277, b3315, eryB, rplV

Function

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. uL4, bL17, and bL20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

Classification

Family (Pfam): PF00237 Ribosomal_L22
InterPro: Ribosomal_uL22, Ribosomal_uL22_bac/chlpt-type, Ribosomal_uL22_bact_org, Ribosomal_uL22_CS, Ribosomal_uL22_sf
Functional cluster: Ribosomal Proteins (S5/S18, L17/L22)

Experimental structures · PDB · 583

2J28 EM 8.00A
2RDO EM 9.10A
3BBX EM 10.00A
3J5L EM 6.60A
3J7Z EM 3.90A
3J8G EM 5.00A
3J9Y EM 3.90A
3J9Z EM 3.60A
3JA1 EM 3.60A
3JBU EM 3.64A
3JBV EM 3.32A
3JCD EM 3.70A
… and 571 more

A predicted model is available from AlphaFold.

Gene Ontology · 12

Drugs targeting this protein · 62

TELITHROMYCIN inhibitor
DEMECLOCYCLINE HYDROCHLORIDE inhibitor
ERYTHROMYCIN LACTOBIONATE inhibitor
ERYTHROMYCIN STEARATE inhibitor
CLINDAMYCIN HYDROCHLORIDE inhibitor
CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
QUINUPRISTIN inhibitor
ERYTHROMYCIN ETHYLSUCCINATE inhibitor
DOXYCYCLINE inhibitor
CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
MINOCYCLINE HYDROCHLORIDE inhibitor
DALFOPRISTIN inhibitor
TETRACYCLINE PHOSPHATE COMPLEX inhibitor
DIRITHROMYCIN inhibitor
TEDIZOLID inhibitor
LINEZOLID inhibitor
CHLORAMPHENICOL inhibitor
TETRACYCLINE inhibitor
KANAMYCIN SULFATE inhibitor
LINCOMYCIN inhibitor
OXYTETRACYCLINE inhibitor
OXYTETRACYCLINE HYDROCHLORIDE inhibitor
DELPAZOLID inhibitor
CLARITHROMYCIN inhibitor
BEKANAMYCIN inhibitor
ERAVACYCLINE inhibitor
OMADACYCLINE TOSYLATE inhibitor
TYLVALOSIN TARTRATE inhibitor
TEDIZOLID PHOSPHATE inhibitor
GAMITHROMYCIN inhibitor
CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
METHACYCLINE HYDROCHLORIDE inhibitor
PAROMOMYCIN SULFATE inhibitor
SISOMICIN inhibitor
ERYTHROMYCIN ESTOLATE inhibitor
ERAVACYCLINE DIHYDROCHLORIDE inhibitor
JOSAMYCIN inhibitor
PLAZOMICIN SULFATE inhibitor
MECLOCYCLINE SULFOSALICYLATE inhibitor
TILDIPIROSIN inhibitor
QUINUPRISTIN/DALFOPRISTIN inhibitor
CLINDAMYCIN PHOSPHATE inhibitor
STREPTOMYCIN SULFATE inhibitor
DIHYDROSTREPTOMYCIN SULFATE inhibitor
CONTEZOLID inhibitor
ERYTHROMYCIN GLUCEPTATE inhibitor
LEFAMULIN ACETATE inhibitor
CADAZOLID inhibitor
TIGECYCLINE inhibitor
OXYTETRACYCLINE CALCIUM inhibitor
SPECTINOMYCIN HYDROCHLORIDE inhibitor
DOXYCYCLINE HYCLATE inhibitor
NETILMICIN SULFATE inhibitor
PIRLIMYCIN HYDROCHLORIDE inhibitor
CETHROMYCIN inhibitor
CONTEZOLID ACEFOSAMIL inhibitor
AMIKACIN SULFATE inhibitor
NAFITHROMYCIN inhibitor
TETRACYCLINE HYDROCHLORIDE inhibitor
RADEZOLID inhibitor
AZITHROMYCIN inhibitor
ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Large ribosomal subunit protein uL4 10 shared papers
Secretion monitor 1 shared papers
Tryptophanase operon leader peptide 3 shared papers
Peptide chain release factor RF2 2 shared papers
Large ribosomal subunit protein uL2 3 shared papers
Large ribosomal subunit protein uL16 3 shared papers
Large ribosomal subunit protein uL3 3 shared papers
Large ribosomal subunit protein uL29 3 shared papers
Large ribosomal subunit protein uL23 3 shared papers
Small ribosomal subunit protein uS17 1 shared papers
Small ribosomal subunit protein uS19 1 shared papers
Small ribosomal subunit protein uS3 1 shared papers

Literature · 23 cited papers

Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling. Nat. Commun. · 2021
Structural basis of L-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide. Nucleic Acids Res. · 2021
Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
Translational termination without a stop codon. Science · 2016
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
The extended loops of ribosomal proteins L4 and L22 are not required for ribosome assembly or L4-mediated autogenous control. RNA · 2003
… and 11 more in the literature graph

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