5-hydroxytryptamine receptor 3B

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.

Classification

Family (Pfam)

PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb

InterPro

5HT3_rcpt, 5HT3_rcpt_B, LGIC_TM_5-HT3, Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM

Functional cluster

Cytochrome P450 & Heme Enzymes

Gene Ontology · 15

• GO:0009986 cell surface
• GO:0043005 neuron projection
• GO:0005886 plasma membrane
• GO:0045211 postsynaptic membrane
• GO:1904602 serotonin-activated cation-selective channel complex
• GO:0045202 synapse
• GO:1902495 transmembrane transporter complex
• GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity
• GO:0022850 serotonin-gated monoatomic cation channel activity
• GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
• GO:0007268 chemical synaptic transmission
• GO:0034220 monoatomic ion transmembrane transport
• GO:0042391 regulation of membrane potential
• GO:0007210 serotonin receptor signaling pathway
• GO:0140227 serotonin-gated cation-selective signaling pathway

Drugs targeting this protein · 12

• PUMOSETRAG partial agonist
• DEXFENFLURAMINE HYDROCHLORIDE agonist
• CILANSETRON antagonist
• TEDATIOXETINE antagonist
• ZIMELDINE HYDROCHLORIDE antagonist
• AMISULPRIDE antagonist
• RENZAPRIDE antagonist
• CLOTHIAPINE antagonist
• RAMOSETRON HYDROCHLORIDE antagonist
• FACINICLINE HYDROCHLORIDE antagonist
• TROPISETRON antagonist
• MOSAPRIDE antagonist

Related proteins · sequence + function similarity

• 5-hydroxytryptamine receptor 3B 0.97
• 5-hydroxytryptamine receptor 3B 0.97
• 5-hydroxytryptamine receptor 3E 0.90
• 5-hydroxytryptamine receptor 3C 0.88
• 5-hydroxytryptamine receptor 3A 0.87
• 5-hydroxytryptamine receptor 3A 0.86
• 5-hydroxytryptamine receptor 3A 0.85
• 5-hydroxytryptamine receptor 3A 0.84
• Acetylcholine receptor subunit gamma 0.81
• Acetylcholine receptor subunit gamma 0.81
• Ligand-gated cation channel ZACN 0.80
• Acetylcholine receptor subunit gamma 0.79

Co-cited proteins · studied together in the literature

• 5-hydroxytryptamine receptor 3A 6 shared papers
• 5-hydroxytryptamine receptor 3C 1 shared papers
• 5-hydroxytryptamine receptor 3D 1 shared papers
• 5-hydroxytryptamine receptor 3E 1 shared papers
• D(1A) dopamine receptor 1 shared papers
• 5-hydroxytryptamine receptor 2B 1 shared papers
• Amine oxidase [flavin-containing] A 1 shared papers
• Sodium-dependent dopamine transporter 1 shared papers
• 5-hydroxytryptamine receptor 2B 1 shared papers
• D(2) dopamine receptor 1 shared papers

Literature · 11 cited papers

• A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature · 2010
• The identification of N-glycosylated residues of the human 5-HT3B receptor subunit: importance for cell membrane expression. J. Neurochem. · 2011
• Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E. Mol. Pharmacol. · 2007
• Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine. Gene · 2007
• Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. Biol. Psychiatry · 2006
• Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients. Am. J. Med. Genet. B Neuropsychiatr. Genet. · 2004
• Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. Clin. Rheumatol. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. Nature · 2003
• The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. J. Biol. Chem. · 1999
• The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature · 1999