5-hydroxytryptamine receptor 3C
Also known as: HTR3C
Function
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Classification
- Family (Pfam)
- PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
- InterPro
- LGIC_TM_5-HT3, Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS
- Functional cluster
- Secreted Growth Factors & Cytokines
Gene Ontology · 14
- GO:0043005 neuron projection
- GO:0005886 plasma membrane
- GO:0045211 postsynaptic membrane
- GO:1904602 serotonin-activated cation-selective channel complex
- GO:0045202 synapse
- GO:1902495 transmembrane transporter complex
- GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity
- GO:0022850 serotonin-gated monoatomic cation channel activity
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
- GO:0007268 chemical synaptic transmission
- GO:0034220 monoatomic ion transmembrane transport
- GO:0042391 regulation of membrane potential
- GO:0007210 serotonin receptor signaling pathway
- GO:0140227 serotonin-gated cation-selective signaling pathway
Drugs targeting this protein · 11
- PUMOSETRAG partial agonist
- DEXFENFLURAMINE HYDROCHLORIDE agonist
- TEDATIOXETINE antagonist
- ZIMELDINE HYDROCHLORIDE antagonist
- AMISULPRIDE antagonist
- RENZAPRIDE antagonist
- CLOTHIAPINE antagonist
- RAMOSETRON HYDROCHLORIDE antagonist
- FACINICLINE HYDROCHLORIDE antagonist
- TROPISETRON antagonist
- MOSAPRIDE antagonist
Related proteins · sequence + function similarity
- 5-hydroxytryptamine receptor 3E 0.98
- 5-hydroxytryptamine receptor 3A 0.91
- 5-hydroxytryptamine receptor 3A 0.89
- 5-hydroxytryptamine receptor 3A 0.89
- 5-hydroxytryptamine receptor 3A 0.88
- 5-hydroxytryptamine receptor 3B 0.88
- 5-hydroxytryptamine receptor 3B 0.82
- 5-hydroxytryptamine receptor 3B 0.82
- Acetylcholine receptor subunit gamma 0.79
- Acetylcholine receptor subunit gamma 0.78
- Acetylcholine receptor subunit gamma 0.77
- Acetylcholine receptor subunit gamma 0.76
Co-cited proteins · studied together in the literature
- 5-hydroxytryptamine receptor 3D 2 shared papers
- 5-hydroxytryptamine receptor 3E 2 shared papers
- 5-hydroxytryptamine receptor 3B 1 shared papers
- 5-hydroxytryptamine receptor 3A 1 shared papers
Literature · 4 cited papers
- Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E. Mol. Pharmacol. · 2007
- The consensus coding sequences of human breast and colorectal cancers. Science · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene · 2003
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