5-hydroxytryptamine receptor 3A

UniProt P46098 Organism Homo sapiens Gene 5HT3R, HTR3, HTR3A

Also known as: 5HT3R, HTR3, HTR3A

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.

Classification

Family (Pfam): PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
InterPro: 5HT3_rcpt, 5HT3_rcpt_A, LGIC_TM_5-HT3, Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS
Functional cluster: Secreted Growth Factors & Cytokines

Experimental structures · PDB · 4

8AXD EM 2.98A
8BL8 EM 3.21A
8BLA EM 3.30A
8BLB EM 3.30A

A predicted model is available from AlphaFold.

Gene Ontology · 18

Drugs targeting this protein · 21

Related proteins · sequence + function similarity

5-hydroxytryptamine receptor 3A 0.99
5-hydroxytryptamine receptor 3A 0.99
5-hydroxytryptamine receptor 3A 0.98
5-hydroxytryptamine receptor 3C 0.89
5-hydroxytryptamine receptor 3E 0.86
5-hydroxytryptamine receptor 3B 0.85
5-hydroxytryptamine receptor 3B 0.82
Acetylcholine receptor subunit gamma 0.82
Acetylcholine receptor subunit gamma 0.82
Acetylcholine receptor subunit gamma 0.81
5-hydroxytryptamine receptor 3B 0.81
Acetylcholine receptor subunit gamma 0.81

Co-cited proteins · studied together in the literature

5-hydroxytryptamine receptor 3B 6 shared papers
Protein RIC-3 1 shared papers
5-hydroxytryptamine receptor 3C 1 shared papers
5-hydroxytryptamine receptor 3D 1 shared papers
5-hydroxytryptamine receptor 3E 1 shared papers
Sex hormone-binding globulin 1 shared papers
Prolyl 4-hydroxylase subunit alpha-1 1 shared papers
Granulocyte colony-stimulating factor 1 shared papers
Inosine-5'-monophosphate dehydrogenase 1 1 shared papers
T-cell surface glycoprotein CD3 delta chain 1 shared papers
Glycine receptor subunit beta 1 shared papers

Literature · 15 cited papers

Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E. Mol. Pharmacol. · 2007
Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. Biol. Psychiatry · 2006
Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3. J. Biol. Chem. · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. Clin. Rheumatol. · 2004
PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. Genomics · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. Nature · 2003
Exon-intron organization of the human 5-HT3A receptor gene. Neuropharmacology · 2000
The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. J. Biol. Chem. · 1999
The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature · 1999
… and 3 more in the literature graph

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