Acetylcholine receptor subunit gamma
Also known as: ACHRG, CHRNG
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Classification
- Family (Pfam)
- PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
- InterPro
- Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS, Nicotinic_acetylcholine_rcpt
- Functional cluster
- Secreted Growth Factors & Cytokines
Gene Ontology · 16
- GO:0005892 acetylcholine-gated channel complex
- GO:0043005 neuron projection
- GO:0005886 plasma membrane
- GO:0045211 postsynaptic membrane
- GO:0045202 synapse
- GO:0015464 acetylcholine receptor activity
- GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity
- GO:0015267 channel activity
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
- GO:0095500 acetylcholine receptor signaling pathway
- GO:0007268 chemical synaptic transmission
- GO:0051899 membrane depolarization
- GO:0034220 monoatomic ion transmembrane transport
- GO:0006936 muscle contraction
- GO:0007165 signal transduction
- GO:0003009 skeletal muscle contraction
Disease associations
- lethal multiple pterygium syndrome MONDO:0009668
- autosomal recessive multiple pterygium syndrome MONDO:0009926
Drugs targeting this protein · 14
- DECAMETHONIUM BROMIDE partial agonist
- ATRACURIUM BESYLATE antagonist
- RAPACURONIUM BROMIDE antagonist
- VECURONIUM BROMIDE antagonist
- CISATRACURIUM BESYLATE antagonist
- ROCURONIUM BROMIDE antagonist
- PIPECURONIUM BROMIDE antagonist
- PANCURONIUM BROMIDE antagonist
- GALLAMINE TRIETHIODIDE antagonist
- DOXACURIUM CHLORIDE antagonist
- METOCURINE IODIDE antagonist
- TUBOCURARINE CHLORIDE antagonist
- SUCCINYLCHOLINE CHLORIDE agonist
- MIVACURIUM CHLORIDE antagonist
Related proteins · sequence + function similarity
- Acetylcholine receptor subunit gamma 0.99
- Acetylcholine receptor subunit gamma 0.98
- Acetylcholine receptor subunit gamma 0.98
- Acetylcholine receptor subunit beta 0.89
- Acetylcholine receptor subunit beta 0.88
- Acetylcholine receptor subunit beta 0.88
- Acetylcholine receptor subunit epsilon 0.88
- Acetylcholine receptor subunit beta 0.87
- Acetylcholine receptor subunit epsilon 0.86
- Acetylcholine receptor subunit epsilon 0.85
- Acetylcholine receptor subunit gamma 0.85
- Acetylcholine receptor subunit epsilon 0.84
Co-cited proteins · studied together in the literature
- Acetylcholine receptor subunit epsilon 1 shared papers
Literature · 7 cited papers
- Mutations in the embryonal subunit of the acetylcholine receptor (CHRNG) cause lethal and Escobar variants of multiple pterygium syndrome. Am. J. Hum. Genet. · 2006
- Escobar syndrome is a prenatal myasthenia caused by disruption of the acetylcholine receptor fetal gamma subunit. Am. J. Hum. Genet. · 2006
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Primary structure of the human muscle acetylcholine receptor. cDNA cloning of the gamma and epsilon subunits. Eur. J. Biochem. · 1993
- Cloning and sequence analysis of human genomic DNA encoding gamma subunit precursor of muscle acetylcholine receptor. Eur. J. Biochem. · 1985
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