Acetylcholine receptor subunit beta

UniProt P11230 Organism Homo sapiens Gene ACHRB, CHRNB, CHRNB1

Also known as: ACHRB, CHRNB, CHRNB1

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Classification

Family (Pfam): PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
InterPro: Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS, Nicotinic_acetylcholine_rcpt
Functional cluster: Secreted Growth Factors & Cytokines

Experimental structures · PDB · 13

9DMG EM 2.05A
9DMH EM 2.06A
9DMJ EM 2.19A
9DMK EM 2.46A
9DML EM 2.24A
9DMQ EM 2.06A
9DMS EM 1.92A
9DMT EM 2.18A
9DMV EM 2.13A
9GU0 EM 2.96A
9GU1 EM 2.48A
9GU2 EM 2.73A
… and 1 more

A predicted model is available from AlphaFold.

Gene Ontology · 26

Disease associations

congenital myasthenic syndrome 2A MONDO:0014581
congenital myasthenic syndrome 2C MONDO:0014582

Drugs targeting this protein · 14

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Acetylcholine receptor subunit delta 3 shared papers
Acetylcholine receptor subunit epsilon 3 shared papers
Acetylcholine receptor subunit alpha 3 shared papers
Alpha-conotoxin ImII 1 shared papers
Alpha-conotoxin ImI 1 shared papers
Neuronal acetylcholine receptor subunit beta-2 1 shared papers
Neuronal acetylcholine receptor subunit alpha-3 1 shared papers
Neuronal acetylcholine receptor subunit beta-4 1 shared papers
Neuronal acetylcholine receptor subunit alpha-3 1 shared papers
Neuronal acetylcholine receptor subunit alpha-7 1 shared papers
Neuronal acetylcholine receptor subunit beta-2 1 shared papers

Literature · 9 cited papers

Mutations causing slow-channel myasthenia reveal that a valine ring in the channel pore of muscle AChR is optimized for stabilizing channel gating. Hum. Mutat. · 2016
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature · 2006
Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry · 2004
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Mutation causing congenital myasthenia reveals acetylcholine receptor beta/delta subunit interaction essential for assembly. J. Clin. Invest. · 1999
New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. Hum. Mol. Genet. · 1996
A beta-subunit mutation in the acetylcholine receptor channel gate causes severe slow-channel syndrome. Ann. Neurol. · 1996
Nucleotide sequence of human muscle acetylcholine receptor beta-subunit. Nucleic Acids Res. · 1989

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