5-hydroxytryptamine receptor 3E

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.

Classification

Family (Pfam)

PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb

InterPro

LGIC_TM_5-HT3, Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS

Functional cluster

Immunoglobulin & Immune-Response Proteins

Gene Ontology · 14

• GO:0043005 neuron projection
• GO:0005886 plasma membrane
• GO:0045211 postsynaptic membrane
• GO:1904602 serotonin-activated cation-selective channel complex
• GO:0045202 synapse
• GO:1902495 transmembrane transporter complex
• GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity
• GO:0022850 serotonin-gated monoatomic cation channel activity
• GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
• GO:0007268 chemical synaptic transmission
• GO:0034220 monoatomic ion transmembrane transport
• GO:0042391 regulation of membrane potential
• GO:0007210 serotonin receptor signaling pathway
• GO:0140227 serotonin-gated cation-selective signaling pathway

Drugs targeting this protein · 11

• PUMOSETRAG partial agonist
• DEXFENFLURAMINE HYDROCHLORIDE agonist
• TEDATIOXETINE antagonist
• ZIMELDINE HYDROCHLORIDE antagonist
• AMISULPRIDE antagonist
• RENZAPRIDE antagonist
• CLOTHIAPINE antagonist
• RAMOSETRON HYDROCHLORIDE antagonist
• FACINICLINE HYDROCHLORIDE antagonist
• TROPISETRON antagonist
• MOSAPRIDE antagonist

Related proteins · sequence + function similarity

• 5-hydroxytryptamine receptor 3C 0.98
• 5-hydroxytryptamine receptor 3B 0.90
• 5-hydroxytryptamine receptor 3A 0.88
• 5-hydroxytryptamine receptor 3A 0.86
• 5-hydroxytryptamine receptor 3A 0.86
• 5-hydroxytryptamine receptor 3B 0.85
• 5-hydroxytryptamine receptor 3A 0.85
• 5-hydroxytryptamine receptor 3B 0.85
• Acetylcholine receptor subunit gamma 0.78
• Acetylcholine receptor subunit gamma 0.77
• 5-hydroxytryptamine receptor 3D 0.77
• Acetylcholine receptor subunit gamma 0.77

Co-cited proteins · studied together in the literature

• 5-hydroxytryptamine receptor 3C 2 shared papers
• 5-hydroxytryptamine receptor 3D 2 shared papers
• 5-hydroxytryptamine receptor 3B 1 shared papers
• 5-hydroxytryptamine receptor 3A 1 shared papers

Literature · 6 cited papers

• Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function. J. Neurochem. · 2009
• Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E. Mol. Pharmacol. · 2007
• The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene · 2003
• Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene · 2003