Glycine receptor subunit beta

UniProt P48167 Organism Homo sapiens Gene GLRB

Also known as: GLRB

Function

Subunit of heteromeric glycine-gated chloride channels. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.

Classification

Family (Pfam): PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
InterPro: Glycine_rcpt_B, GlyR_beta__ECD, GlyR_beta_TM, Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS
Functional cluster: Secreted Hydrolases & Toxins

Experimental structures · PDB · 12

5BKF EM 3.60A
5BKG EM 3.80A
7KUY EM 3.60A
7L31 EM 3.80A
8DN2 EM 3.90A
8DN3 EM 3.55A
8DN4 EM 4.10A
8DN5 EM 3.63A
9BOY EM 3.81A
9BOZ EM 3.84A
9BP0 EM 3.67A
9BP7 EM 3.60A

A predicted model is available from AlphaFold.

Gene Ontology · 22

Disease associations

hyperekplexia 2 MONDO:0013828

Drugs targeting this protein · 6

SEVOFLURANE positive modulator
DESFLURANE positive modulator
ISOFLURANE positive modulator
ENFLURANE positive modulator
METHOXYFLURANE agonist
HALOTHANE positive modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Glycine receptor subunit alpha-1 7 shared papers
Glycine receptor subunit alpha-2 4 shared papers
Gephyrin 2 shared papers
Glycine receptor subunit alpha-1 1 shared papers
Gamma-aminobutyric acid receptor subunit alpha-3 1 shared papers
Gephyrin 1 shared papers
Sex hormone-binding globulin 1 shared papers
Glycine receptor subunit alpha-3 1 shared papers
Glycine receptor subunit beta 1 shared papers
Prolyl 4-hydroxylase subunit alpha-1 1 shared papers
Granulocyte colony-stimulating factor 1 shared papers
Inosine-5'-monophosphate dehydrogenase 1 1 shared papers

Literature · 20 cited papers

Asymmetric gating of a human hetero-pentameric glycine receptor. Nat. Commun. · 2023
Clinical, genetic, and functional characterization of the glycine receptor beta-subunit A455P variant in a family affected by hyperekplexia syndrome. J. Biol. Chem. · 2022
Characterization of the subunit composition and structure of adult human glycine receptors. Neuron · 2021
Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy. EMBO Mol. Med. · 2015
Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations. Neuropharmacology · 2015
Novel missense mutations in the glycine receptor beta subunit gene (GLRB) in startle disease. Neurobiol. Dis. · 2013
Stoichiometry of the human glycine receptor revealed by direct subunit counting. J. Neurosci. · 2012
Stoichiometry and subunit arrangement of alpha1beta glycine receptors as determined by atomic force microscopy. Biochemistry · 2012
Novel mutation in GLRB in a large family with hereditary hyperekplexia. Clin. Genet. · 2012
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors. J. Biol. Chem. · 2005
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
… and 8 more in the literature graph

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