D(1A) dopamine receptor
Also known as: DRD1
Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Forms heterotetramers with DRD3 to potentiate beta-arrestin recruitment and mediate locomotor activity.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- Dopamine_D1_rcpt, Dopamine_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 24
- 7CKW EM 3.22A
- 7CKX EM 3.54A
- 7CKY EM 3.20A
- 7CKZ EM 3.10A
- 7CRH EM 3.30A
- 7F0T EM 3.10A
- 7F1O EM 3.13A
- 7F1Z EM 3.46A
- 7F23 EM 3.58A
- 7F24 EM 4.16A
- 7JOZ X-ray 3.80A
- 7JV5 EM 3.00A
- … and 12 more
A predicted model is available from AlphaFold.
Gene Ontology · 44
- GO:0097731 9+0 non-motile cilium
- GO:0060170 ciliary membrane
- GO:0005929 cilium
- GO:0043197 dendritic spine
- GO:0005789 endoplasmic reticulum membrane
- GO:0097648 G protein-coupled receptor complex
- GO:0098982 GABA-ergic synapse
- GO:0098978 glutamatergic synapse
- GO:0097730 non-motile cilium
- GO:0005634 nucleus
- GO:0005886 plasma membrane
- GO:0045211 postsynaptic membrane
- GO:0042734 presynaptic membrane
- GO:1990763 arrestin family protein binding
- GO:0035240 dopamine binding
- GO:0004952 dopamine neurotransmitter receptor activity
- GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs
- GO:0004930 G protein-coupled receptor activity
- GO:0001965 G-protein alpha-subunit binding
- GO:0032795 heterotrimeric G-protein binding
- GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
- GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0007628 adult walking behavior
- GO:0071870 cellular response to catecholamine stimulus
- GO:0021853 cerebral cortex GABAergic interneuron migration
- GO:0042417 dopamine metabolic process
- GO:0007212 G protein-coupled dopamine receptor signaling pathway
- GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- GO:0007617 mating behavior
- GO:0099010 modification of postsynaptic structure
- GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
- GO:0030335 positive regulation of cell migration
- GO:0043410 positive regulation of MAPK cascade
- GO:0043268 positive regulation of potassium ion transport
- GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
- GO:0051968 positive regulation of synaptic transmission, glutamatergic
- GO:0099171 presynaptic modulation of chemical synaptic transmission
- GO:0051584 regulation of dopamine uptake involved in synaptic transmission
- GO:0009410 response to xenobiotic stimulus
- GO:0007416 synapse assembly
- GO:0019226 transmission of nerve impulse
- GO:0042311 vasodilation
- GO:0008542 visual learning
Drugs targeting this protein · 12
- FENOLDOPAM MESYLATE agonist
- AMOXAPINE antagonist
- METHYLERGONOVINE MALEATE antagonist
- PERGOLIDE MESYLATE agonist
- MINAPRINE HYDROCHLORIDE agonist
- PIMOZIDE antagonist
- ERGOLOID MESYLATES agonist
- MINAPRINE agonist
- ECOPIPAM antagonist
- MEVIDALEN positive allosteric modulator
- TAVAPADON partial agonist
- AMINEPTINE antagonist
Related proteins · sequence + function similarity
- D(1A) dopamine receptor 1.00
- D(1A) dopamine receptor 0.99
- D(1A) dopamine receptor 0.99
- D(1A) dopamine receptor 0.99
- D(1A) dopamine receptor 0.98
- D(1A) dopamine receptor 0.98
- D(1A) dopamine receptor 0.98
- D(1)-like dopamine receptor 0.96
- D(1C) dopamine receptor 0.95
- D(1B) dopamine receptor 0.95
- D(1) dopamine receptor 0.94
- 5-hydroxytryptamine receptor 1 0.93
Co-cited proteins · studied together in the literature
- G protein-coupled receptor 88 1 shared papers
- D(1A) dopamine receptor 1 shared papers
- Kinesin-like protein KIF17 1 shared papers
- Ras-related protein Rab-23 1 shared papers
- Intraflagellar transport protein 57 homolog 1 shared papers
- 5-hydroxytryptamine receptor 2B 1 shared papers
- 5-hydroxytryptamine receptor 3B 1 shared papers
- Amine oxidase [flavin-containing] A 1 shared papers
- Sodium-dependent dopamine transporter 1 shared papers
- 5-hydroxytryptamine receptor 2B 1 shared papers
- D(2) dopamine receptor 1 shared papers
Literature · 10 cited papers
- Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia. Elife · 2015
- GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk. PLoS ONE · 2013
- A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature · 2010
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor. Eur. J. Pharmacol. · 1999
- Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms. Neuropsychopharmacology · 1993
- Cloning and expression of human and rat D1 dopamine receptors. Nature · 1990
- Molecular cloning and expression of the gene for a human D1 dopamine receptor. Nature · 1990
- Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature · 1990
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