Amine oxidase [flavin-containing] A

UniProt P21397 Organism Homo sapiens Gene MAOA EC 1.4.3.21, 1.4.3.4

Also known as: MAOA

Function

Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).

Classification

Family (Pfam): PF01593 Amino_oxidase
InterPro: Amino_oxidase, FAD/NAD-bd_sf, Flavin_amine_oxidase, Flavin_MAO
Functional cluster: Oxidoreductases & Polyketide Synthases

Experimental structures · PDB · 4

2BXR X-ray 3.00A
2BXS X-ray 3.15A
2Z5X X-ray 2.20A
2Z5Y X-ray 2.17A

A predicted model is available from AlphaFold.

Gene Ontology · 9

Disease associations

Brunner syndrome MONDO:0010379

Drugs targeting this protein · 13

PARGYLINE HYDROCHLORIDE inhibitor
PHENELZINE SULFATE inhibitor
ISOCARBOXAZID inhibitor
NIALAMIDE inhibitor
MINAPRINE HYDROCHLORIDE inhibitor
TOLOXATONE inhibitor
MEBANAZINE inhibitor
PHENOXYPROPAZINE inhibitor
PROXIBARBAL activator
MINAPRINE inhibitor
TRANYLCYPROMINE SULFATE inhibitor
MOCLOBEMIDE inhibitor
IPRONIAZID inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Amine oxidase [flavin-containing] B 5 shared papers
Amine oxidase [flavin-containing] A 2 shared papers
Amine oxidase [flavin-containing] B 1 shared papers
Amine oxidase [flavin-containing] B 1 shared papers
Dedicator of cytokinesis protein 8 1 shared papers
Histone deacetylase 4 1 shared papers
D(1A) dopamine receptor 1 shared papers
5-hydroxytryptamine receptor 2B 1 shared papers
5-hydroxytryptamine receptor 3B 1 shared papers
Sodium-dependent dopamine transporter 1 shared papers
5-hydroxytryptamine receptor 2B 1 shared papers
D(2) dopamine receptor 1 shared papers

Literature · 23 cited papers

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
20 ans apres: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition. Eur. J. Hum. Genet. · 2014
A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature · 2010
The oxidation of adrenaline and noradrenaline by the two forms of monoamine oxidase from human and rat brain. Neurochem. Int. · 1986
Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors. Proc. Natl. Acad. Sci. U.S.A. · 2008
The consensus coding sequences of human breast and colorectal cancers. Science · 2006
Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. Proc. Natl. Acad. Sci. U.S.A. · 2005
The DNA sequence of the human X chromosome. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
High-level expression of human liver monoamine oxidase A in Pichia pastoris: comparison with the enzyme expressed in Saccharomyces cerevisiae. Protein Expr. Purif. · 2002
A functional polymorphism in the monoamine oxidase A gene promoter. Hum. Genet. · 1998
… and 11 more in the literature graph

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.