Amine oxidase [flavin-containing] B

UniProt P27338 Organism Homo sapiens Gene MAOB EC 1.4.3.21, 1.4.3.4

Also known as: MAOB

Function

Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.

Classification

Family (Pfam): PF01593 Amino_oxidase
InterPro: Amino_oxidase, FAD/NAD-bd_sf, Flavin_amine_oxidase, Flavin_MAO
Functional cluster: RuBisCO & Carbon-Fixation Enzymes

Experimental structures · PDB · 56

1GOS X-ray 3.00A
1OJ9 X-ray 2.30A
1OJA X-ray 1.70A
1OJC X-ray 2.40A
1OJD X-ray 3.10A
1S2Q X-ray 2.07A
1S2Y X-ray 2.12A
1S3B X-ray 1.65A
1S3E X-ray 1.60A
2BK3 X-ray 1.80A
2BK4 X-ray 1.90A
2BK5 X-ray 1.83A
… and 44 more

A predicted model is available from AlphaFold.

Gene Ontology · 11

Drugs targeting this protein · 15

PARGYLINE HYDROCHLORIDE inhibitor
PHENELZINE SULFATE inhibitor
SELEGILINE HYDROCHLORIDE inhibitor
RASAGILINE MESYLATE inhibitor
ISOCARBOXAZID inhibitor
NIALAMIDE inhibitor
MEBANAZINE inhibitor
PHENOXYPROPAZINE inhibitor
RALFINAMIDE inhibitor
SAFINAMIDE inhibitor
TRANYLCYPROMINE SULFATE inhibitor
SAFINAMIDE MESYLATE inhibitor
RASAGILINE TARTRATE inhibitor
IPRONIAZID inhibitor
SELEGILINE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Amine oxidase [flavin-containing] A 5 shared papers
Amine oxidase [flavin-containing] B 1 shared papers
Amine oxidase [flavin-containing] A 1 shared papers
Amine oxidase [flavin-containing] B 1 shared papers

Literature · 17 cited papers

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
The oxidation of adrenaline and noradrenaline by the two forms of monoamine oxidase from human and rat brain. Neurochem. Int. · 1986
Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis. J. Med. Chem. · 2005
The DNA sequence of the human X chromosome. Nature · 2005
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J. Biol. Chem. · 2005
Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class. J. Med. Chem. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures. Proc. Natl. Acad. Sci. U.S.A. · 2003
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nat. Struct. Biol. · 2002
Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid. J. Biol. Chem. · 2001
High-level expression of human liver monoamine oxidase B in Pichia pastoris. Protein Expr. Purif. · 2000
Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis. Eur. J. Biochem. · 1996
… and 5 more in the literature graph

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