Glutamate receptor ionotropic, kainate 5
Also known as: GRIK2, GRIK5
Function
Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and produces channel activity only in heteromeric assembly with GRIK1 and GRIK2 subunits. Can form functional heteromeric receptors with GRIK3 (By similarity).
Classification
- Family (Pfam)
- PF01094 ANF_receptor, PF00060 Lig_chan, PF10613 Lig_chan-Glu_bd
- InterPro
- ANF_lig-bd_rcpt, Glu/Gly-bd, Iono_Glu_rcpt_met, Ionotropic_Glu_rcpt, Iontro_rcpt_C, Peripla_BP_I
- Functional cluster
- Cytochrome P450 & Heme Enzymes
Gene Ontology · 13
- GO:0005783 endoplasmic reticulum
- GO:0098978 glutamatergic synapse
- GO:0098686 hippocampal mossy fiber to CA3 synapse
- GO:0032983 kainate selective glutamate receptor complex
- GO:0005886 plasma membrane
- GO:0098839 postsynaptic density membrane
- GO:0042734 presynaptic membrane
- GO:0015277 kainate selective glutamate receptor activity
- GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
- GO:0007215 glutamate receptor signaling pathway
- GO:0050804 modulation of chemical synaptic transmission
- GO:0035249 synaptic transmission, glutamatergic
Drugs targeting this protein · 3
- TOPIRAMATE antagonist
- SELURAMPANEL antagonist
- TEZAMPANEL antagonist
Related proteins · sequence + function similarity
- Glutamate receptor ionotropic, kainate 5 1.00
- Glutamate receptor ionotropic, kainate 5 1.00
- Glutamate receptor ionotropic, kainate 4 0.97
- Glutamate receptor ionotropic, kainate 4 0.97
- Glutamate receptor ionotropic, kainate 4 0.97
- Glutamate receptor ionotropic, kainate 4 0.96
- Glutamate receptor ionotropic, kainate 3 0.91
- Glutamate receptor ionotropic, kainate 3 0.91
- Glutamate receptor ionotropic, kainate 3 0.91
- Glutamate receptor ionotropic, kainate 3 0.90
- Glutamate receptor ionotropic, kainate 2 0.90
- Glutamate receptor ionotropic, kainate 2 0.89
Co-cited proteins · studied together in the literature
- Glutamate receptor ionotropic, kainate 2 2 shared papers
- Glutamate receptor ionotropic, kainate 1 1 shared papers
Literature · 3 cited papers
- Trafficking and surface expression of the glutamate receptor subunit, KA2. Biochem. Biophys. Res. Commun. · 2003
- Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors. J. Physiol. (Lond.) · 1996
- Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit. Mol. Pharmacol. · 1992
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