Glutamate receptor ionotropic, kainate 2

UniProt Q13002 Organism Homo sapiens Gene GLUR6, GRIK2

Also known as: GLUR6, GRIK2

Function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse (By similarity). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2 (By similarity). In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity).

Classification

Family (Pfam): PF01094 ANF_receptor, PF00060 Lig_chan, PF10613 Lig_chan-Glu_bd
InterPro: ANF_lig-bd_rcpt, Glu/Gly-bd, Iono_Glu_rcpt_met, Ionotropic_Glu_rcpt, Iontro_rcpt_C, Peripla_BP_I
Functional cluster: Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 2

3QXM X-ray 1.65A
5CMM X-ray 1.27A

A predicted model is available from AlphaFold.

Gene Ontology · 35

Disease associations

intellectual disability, autosomal recessive 6 MONDO:0012614
neurodevelopmental disorder with impaired language and ataxia and with or without seizures MONDO:0859201

Drugs targeting this protein · 3

TOPIRAMATE antagonist
SELURAMPANEL antagonist
TEZAMPANEL antagonist

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Glutamate receptor ionotropic, kainate 1 3 shared papers
Glutamate receptor ionotropic, kainate 5 2 shared papers
Glutamate receptor 2 1 shared papers
Glutamate receptor ionotropic, kainate 2 1 shared papers
Glutamate receptor ionotropic, kainate glr-3 1 shared papers
Glutamate receptor ionotropic, kainate 2 1 shared papers
Disks large homolog 4 1 shared papers
Glutamate receptor ionotropic, kainate 2 1 shared papers
Guanine nucleotide-binding protein G(o) subunit alpha 1 shared papers

Literature · 17 cited papers

Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders. Am. J. Hum. Genet. · 2021
A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene. Cell · 2019
A gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficits. Neurol. Genet. · 2017
Modification and movement: Phosphorylation and SUMOylation regulate endocytosis of GluK2-containing kainate receptors. Commun. Integr. Biol. · 2012
Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors. J. Mol. Biol. · 2011
Novel spliced variants of ionotropic glutamate receptor GluR6 in normal human fibroblast and brain cells are transcribed by tissue specific promoters. Gene · 2010
A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation. Am. J. Hum. Genet. · 2007
The consensus coding sequences of human breast and colorectal cancers. Science · 2006
The DNA sequence and analysis of human chromosome 6. Nature · 2003
Trafficking and surface expression of the glutamate receptor subunit, KA2. Biochem. Biophys. Res. Commun. · 2003
The PDZ1 domain of SAP90. Characterization of structure and binding. J. Biol. Chem. · 2002
Genomic organization of the human GRIK2 gene and characterization of multiple splicing variants. Gene · 2001
… and 5 more in the literature graph

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