Glutamate receptor ionotropic, kainate 3
Also known as: GLUR7, GRIK3
Function
Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity).
Classification
- Family (Pfam)
- PF01094 ANF_receptor, PF00060 Lig_chan, PF10613 Lig_chan-Glu_bd
- InterPro
- ANF_lig-bd_rcpt, Glu/Gly-bd, Iono_Glu_rcpt_met, Ionotropic_Glu_rcpt, Iontro_rcpt_C, Peripla_BP_I
- Functional cluster
- Immunoglobulin-Domain Cell Adhesion Proteins
Gene Ontology · 23
- GO:0030424 axon
- GO:0030425 dendrite
- GO:0032839 dendrite cytoplasm
- GO:0098978 glutamatergic synapse
- GO:0032983 kainate selective glutamate receptor complex
- GO:0043204 perikaryon
- GO:0005886 plasma membrane
- GO:0098839 postsynaptic density membrane
- GO:0042734 presynaptic membrane
- GO:0043195 terminal bouton
- GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
- GO:0008066 glutamate receptor activity
- GO:0022849 glutamate-gated calcium ion channel activity
- GO:0004970 glutamate-gated receptor activity
- GO:0015277 kainate selective glutamate receptor activity
- GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
- GO:0007216 G protein-coupled glutamate receptor signaling pathway
- GO:0007215 glutamate receptor signaling pathway
- GO:0050804 modulation of chemical synaptic transmission
- GO:0051967 negative regulation of synaptic transmission, glutamatergic
- GO:0042391 regulation of membrane potential
- GO:0035249 synaptic transmission, glutamatergic
Drugs targeting this protein · 3
- TOPIRAMATE antagonist
- SELURAMPANEL antagonist
- TEZAMPANEL antagonist
Related proteins · sequence + function similarity
- Glutamate receptor ionotropic, kainate 3 1.00
- Glutamate receptor ionotropic, kainate 3 1.00
- Glutamate receptor ionotropic, kainate 3 1.00
- Glutamate receptor ionotropic, kainate 2 0.99
- Glutamate receptor ionotropic, kainate 2 0.99
- Glutamate receptor ionotropic, kainate 2 0.98
- Glutamate receptor ionotropic, kainate 2 0.98
- Glutamate receptor ionotropic, kainate 2 0.98
- Glutamate receptor ionotropic, kainate 2 0.98
- Glutamate receptor ionotropic, kainate 1 0.97
- Glutamate receptor ionotropic, kainate 1 0.97
- Glutamate receptor ionotropic, kainate 1 0.97
Co-cited proteins · studied together in the literature
- Glutamate receptor ionotropic, kainate 3 1 shared papers
Literature · 5 cited papers
- The consensus coding sequences of human breast and colorectal cancers. Science · 2006
- The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
- Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. J. Neurosci. · 2000
- Chromosomal localization of gene for human glutamate receptor subunit-7. Somat. Cell Mol. Genet. · 1993
- Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites. Recept. Channels · 1994
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