lmmol · Proteins

Glutamate receptor ionotropic, kainate 1

UniProt P39086 Organism Homo sapiens Gene GLUR5, GRIK1

Also known as: GLUR5, GRIK1

Function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

Classification

Family (Pfam)
PF01094 ANF_receptor, PF00060 Lig_chan, PF10613 Lig_chan-Glu_bd
InterPro
ANF_lig-bd_rcpt, Glu/Gly-bd, Iono_Glu_rcpt_met, Ionotropic_Glu_rcpt, Iontro_rcpt_C, Peripla_BP_I
Functional cluster
Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 11

A predicted model is available from AlphaFold.

Gene Ontology · 16

Drugs targeting this protein · 4

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 6 cited papers

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