Glutamate receptor ionotropic, kainate 4
Also known as: GRIK, GRIK4
Function
Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel. Cannot form functional channels on its own. Shows channel activity only in heteromeric assembly with GRIK1, GRIK2 and GRIK3 subunits (By similarity).
Classification
- Family (Pfam)
- PF01094 ANF_receptor, PF00060 Lig_chan, PF10613 Lig_chan-Glu_bd
- InterPro
- ANF_lig-bd_rcpt, Glu/Gly-bd, Iono_Glu_rcpt_met, Ionotropic_Glu_rcpt, Iontro_rcpt_C, Peripla_BP_I
- Functional cluster
- Cytochrome P450 & Heme Enzymes
Gene Ontology · 13
- GO:0098978 glutamatergic synapse
- GO:0098686 hippocampal mossy fiber to CA3 synapse
- GO:0032983 kainate selective glutamate receptor complex
- GO:0005886 plasma membrane
- GO:0098839 postsynaptic density membrane
- GO:0042734 presynaptic membrane
- GO:0015277 kainate selective glutamate receptor activity
- GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
- GO:0007268 chemical synaptic transmission
- GO:0007215 glutamate receptor signaling pathway
- GO:0050804 modulation of chemical synaptic transmission
- GO:0035249 synaptic transmission, glutamatergic
Drugs targeting this protein · 3
- TOPIRAMATE antagonist
- SELURAMPANEL antagonist
- TEZAMPANEL antagonist
Related proteins · sequence + function similarity
- Glutamate receptor ionotropic, kainate 4 1.00
- Glutamate receptor ionotropic, kainate 4 1.00
- Glutamate receptor ionotropic, kainate 4 1.00
- Glutamate receptor ionotropic, kainate 5 0.97
- Glutamate receptor ionotropic, kainate 5 0.97
- Glutamate receptor ionotropic, kainate 5 0.97
- Glutamate receptor ionotropic, kainate 3 0.94
- Glutamate receptor ionotropic, kainate 3 0.94
- Glutamate receptor ionotropic, kainate 3 0.94
- Glutamate receptor ionotropic, kainate 3 0.93
- Glutamate receptor ionotropic, kainate 2 0.93
- Glutamate receptor ionotropic, kainate 2 0.92
Literature · 2 cited papers
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.