Voltage-dependent L-type calcium channel subunit beta-3
Also known as: CACNB3, CACNLB3
Function
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
Classification
- Family (Pfam)
- PF00625 Guanylate_kin, PF12052 VGCC_beta4Aa_N
- InterPro
- CAB1-4_N_A-dom, CACNB3_SH3, GK/Ca_channel_bsu, P-loop_NTPase, SH3-like_dom_sf, SH3_domain, VDCC_L_b3su, VDCC_L_bsu
- Functional cluster
- RNA Polymerase II Transcription Factors
Experimental structures · PDB · 16
- 7MIX EM 3.00A
- 7MIY EM 3.10A
- 7UHF EM 3.10A
- 7UHG EM 3.00A
- 8E59 EM 3.10A
- 8E5A EM 3.30A
- 8E5B EM 3.30A
- 8EPL EM 3.10A
- 8FHS EM 3.30A
- 8WE6 EM 2.90A
- 8WE7 EM 3.20A
- 8WE8 EM 2.90A
- … and 4 more
A predicted model is available from AlphaFold.
Gene Ontology · 18
- GO:0005829 cytosol
- GO:1990454 L-type voltage-gated calcium channel complex
- GO:0016020 membrane
- GO:0045202 synapse
- GO:0030315 T-tubule
- GO:0005891 voltage-gated calcium channel complex
- GO:0005246 calcium channel regulator activity
- GO:0008331 high voltage-gated calcium channel activity
- GO:0005245 voltage-gated calcium channel activity
- GO:0070588 calcium ion transmembrane transport
- GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel
- GO:0006816 calcium ion transport
- GO:0060402 calcium ion transport into cytosol
- GO:0007268 chemical synaptic transmission
- GO:1901843 positive regulation of high voltage-gated calcium channel activity
- GO:0045933 positive regulation of muscle contraction
- GO:0072659 protein localization to plasma membrane
- GO:0098903 regulation of membrane repolarization during action potential
Drugs targeting this protein · 9
- PREGABALIN modulator
- BEPRIDIL HYDROCHLORIDE blocker
- GABAPENTIN ENACARBIL modulator
- IMAGABALIN modulator
- SULOCTIDIL blocker
- PHLOROGLUCINOL blocker
- TERODILINE HYDROCHLORIDE blocker
- ATAGABALIN modulator
- GABAPENTIN modulator
Related proteins · sequence + function similarity
- Voltage-dependent L-type calcium channel subunit beta-3 1.00
- Voltage-dependent L-type calcium channel subunit beta-3 1.00
- Voltage-dependent L-type calcium channel subunit beta-3 1.00
- Voltage-dependent L-type calcium channel subunit beta-3 1.00
- Voltage-dependent L-type calcium channel subunit beta-1 0.93
- Voltage-dependent L-type calcium channel subunit beta-1 0.93
- Voltage-dependent L-type calcium channel subunit beta-1 0.93
- Voltage-dependent L-type calcium channel subunit beta-1 0.93
- Voltage-dependent L-type calcium channel subunit beta-1 0.91
- Voltage-dependent L-type calcium channel subunit beta-2 0.88
- Voltage-dependent L-type calcium channel subunit beta-2 0.87
- Voltage-dependent L-type calcium channel subunit beta-2 0.85
Co-cited proteins · studied together in the literature
- Voltage-dependent L-type calcium channel subunit alpha-1D 1 shared papers
- Voltage-dependent N-type calcium channel subunit alpha-1B 1 shared papers
- Voltage-dependent calcium channel subunit alpha-2/delta-1 2 shared papers
- Voltage-dependent calcium channel subunit alpha-2/delta-4 1 shared papers
- Voltage-dependent L-type calcium channel subunit alpha-1C 3 shared papers
- Voltage-dependent L-type calcium channel subunit beta-3 1 shared papers
- Voltage-dependent calcium channel subunit alpha-2/delta-3 1 shared papers
- Calciseptine 1 shared papers
- Omega-conotoxin MVIIA 1 shared papers
Literature · 10 cited papers
- Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell · 2023
- Structure of human Cav2.2 channel blocked by the painkiller ziconotide. Nature · 2021
- Alternative Splicing at N Terminus and Domain I Modulates CaV1.2 Inactivation and Surface Expression. Biophys. J. · 2018
- Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. BMC Immunol. · 2009
- The finished DNA sequence of human chromosome 12. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. Mol. Pharmacol. · 2002
- Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit. Eur. J. Biochem. · 1994
- The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes. Genomics · 1995
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