Voltage-dependent L-type calcium channel subunit beta-1

UniProt Q02641 Organism Homo sapiens Gene CACNB1, CACNLB1

Also known as: CACNB1, CACNLB1

Function

Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit.

Classification

Family (Pfam): PF00625 Guanylate_kin, PF12052 VGCC_beta4Aa_N
InterPro: CAB1-4_N_A-dom, GK/Ca_channel_bsu, P-loop_NTPase, SH3-like_dom_sf, SH3_domain, VDCC_L_b1su, VDCC_L_bsu
Functional cluster: RNA Polymerase II Transcription Factors

Experimental structures · PDB · 6

7VFS EM 2.80A
7VFU EM 3.00A
7VFV EM 3.00A
7VFW EM 3.30A
7XLQ EM 3.10A
7YG5 EM 3.00A

A predicted model is available from AlphaFold.

Gene Ontology · 13

Drugs targeting this protein · 9

PREGABALIN modulator
BEPRIDIL HYDROCHLORIDE blocker
GABAPENTIN ENACARBIL modulator
IMAGABALIN modulator
SULOCTIDIL blocker
PHLOROGLUCINOL blocker
TERODILINE HYDROCHLORIDE blocker
ATAGABALIN modulator
GABAPENTIN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Voltage-dependent calcium channel subunit alpha-2/delta-1 2 shared papers
Voltage-dependent L-type calcium channel subunit beta-1 1 shared papers
Voltage-dependent L-type calcium channel subunit alpha-1C 1 shared papers
Voltage-dependent L-type calcium channel subunit alpha-1D 1 shared papers

Literature · 11 cited papers

The consensus coding sequences of human breast and colorectal cancers. Science · 2006
Unique modulation of L-type Ca2+ channels by short auxiliary beta1d subunit present in cardiac muscle. Am. J. Physiol. · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels. Neurosci. Lett. · 1999
Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes. Neurosci. Lett. · 1996
Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility. Hum. Mol. Genet. · 1993
Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly. Neuropharmacology · 1993
Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart. Circ. Res. · 1993
Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene. J. Biol. Chem. · 1992
Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. Neuron · 1992

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